IgM myeloma:: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14)

被引：47

作者：

Feyler, Sylvia ^{[1
]}

O'Connor, Sheila J. M. ^{[2
]}

Rawstron, Andy C. ^{[2
]}

Subash, Chezhian ^{[1
]}

Ross, Fiona M. ^{[3
]}

Pratt, Guy ^{[4
]}

Drayson, Mark T. ^{[5
]}

Ashcroft, John ^{[6
]}

Cook, Gordon ^{[1
]}

Owen, Roger G. ^{[1
,2
]}

机构：

[1] St James Univ Hosp, Leeds LS9 7TF, W Yorkshire, England

[2] Leeds Teaching Hosp NHS Trust, HMDS Lab, Leeds, W Yorkshire, England

[3] Wessex Reg Cytogenet Lab, LRF UK Myeloma Forum Cytogenet Database, Salisbury, Wilts, England

[4] Birmingham Heartlands Hosp, Birmingham B9 5ST, W Midlands, England

[5] Univ Birmingham, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

[6] Midyorkshire NHS Trust, Wakefield, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 140卷 / 05期

关键词：

IgM; myeloma; immunophenotype; t(11; 14); genotype;

D O I：

10.1111/j.1365-2141.2007.06969.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IgM myeloma is a very rare and poorly defined entity. In a detailed assessment of 10 cases, it was demonstrated that 70% had an aberrant phenotype based on the expression of CD19, CD45, CD27 and Cyclin D1 but all cases lacked CD56 and CD117. Interphase fluorescence in situ hybridization demonstrated deletion 13 in 50% while 5/8 cases assessed had a t(11;14). Despite the high incidence of the t(11;14), CD20 was only expressed in one of nine cases. We conclude that IgM myeloma is a distinctive subset characterized by a CD20(-)CD56(-)CD117(-) phenotype and the t(11;14).

引用

页码：547 / 551

页数：5

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