Anti-arthritic Active Fraction of Capparis Spinosa L. Fruits and Its Chemical Constituents

被引：42

作者：

Feng, Xiaolu ^{[1
,2
]}

Lu, Jincai ^{[2
]}

Xin, Hailiang ^{[4
]}

Zhang, Lei ^{[3
]}

Wang, Yuliang ^{[1
]}

Tang, Kexuan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Agr & Biol, Plant Biotechnol Res Ctr, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Shanghai 200240, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Pharmacognosy, Shenyang 110016, Peoples R China

[3] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[4] Second Mil Med Univ, Sch Pharm, Dept Tradit Chinese Med, Shanghai 200433, Peoples R China

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2011年 / 131卷 / 03期

关键词：

Capparis spinosa L. (Capparidaceae); arthritic; stachydrine; ARTHRITIS; EXPRESSION; EXTRACTS; RATS;

D O I：

10.1248/yakushi.131.423

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50 : 50, v/v) had the most significant anti-arthritic activity. The chemical constituents of this fraction were therefore studied; seven known compounds were isolated and identified as: (1) P-hydroxy benzoic acid; (2) 5- (hydroxymethyl) furfural; (3) bis (5-formylfurfuryl) ether; (4) daucosterol; (5) alpha-D-fructofuranosides methyl; (6) uracil; and (7) stachydrine.

引用

页码：423 / 429

页数：7

共 26 条

[1] Antifungal activity of plant extracts against dermatophytes [J].