Critical Review on the Analytical Techniques for the Determination of the Oldest Statin-Atorvastatin-in Bulk, Pharmaceutical Formulations and Biological Fluids

被引：16
|
作者：
Kokilambigai, K. S. [1 ]
Seetharaman, R. [1 ]
Lakshmi, K. S. [1 ]
机构：
[1] SRM Univ, Dept Pharmaceut Anal, SRM Coll Pharm, Kanchipuram 603203, Tamil Nadu, India
来源：
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2017年 / 47卷 / 06期
关键词：
Atorvastatin; biological fluids; pharmaceutical formulations; review; RP-HPLC METHOD; PERFORMANCE LIQUID-CHROMATOGRAPHY; PARA-HYDROXY ATORVASTATIN; SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION; SIMULTANEOUS HPTLC ANALYSIS; HUMAN PLASMA; AMLODIPINE BESYLATE; CAPILLARY-ELECTROPHORESIS; RATIO SPECTRA; DERIVATIVE SPECTROPHOTOMETRY;
D O I：
10.1080/10408347.2017.1342529
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Statins are a group of medicines that can help to lower the level of low-density lipoprotein (LDL) cholesterol bad cholesterol in the blood. Having a high level of LDL cholesterol is potentially dangerous, as it can lead to a hardening and narrowing of arteries (atherosclerosis) and cardiovascular disease (CVD), atorvastatin is one of the oldest member of the statin family and is used in the treatment of dyslipidemia and the prevention of CVD. Atorvastatin was first made in August 1985 and from 1996 to 2012 under the trade name Lipitor, atorvastatin became the world's best-selling drug. Numerous analytical methodologies are available for the quantification of atorvastatin and its content in pharmaceutical preparations and in biological fluids.
引用
收藏
页码：538 / 555
页数：18
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