A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain

被引：3
|
作者：
Drissya, Thankappan [1 ,2 ]
Induja, D. K. [2 ,3 ]
Poornima, M. S. [1 ,2 ]
Jesmina, A. R. S. [1 ,2 ]
Prabha, Bernard [3 ]
Saumini, Mathew [2 ,3 ]
Suresh, Cherumuttathu H. [2 ,3 ]
Raghu, K. G. [1 ,2 ]
Kumar, B. S. Dileep [1 ,2 ]
Lankalapalli, Ravi S. [2 ,3 ]
机构：
[1] CSIR, Agroproc & Technol Div, Natl Inst Interdisciplinary Sci & Technol, Thiruvananthapuram 695019, Kerala, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
[3] CSIR, Chem Sci & Technol Div, Natl Inst Interdisciplinary Sci & Technol, Thiruvananthapuram 695019, Kerala, India
来源：
JOURNAL OF ANTIBIOTICS | 2022年 / 75卷 / 09期
关键词：
DIFFERENTIATION; BENZAMIDES; DC92-B;
D O I：
10.1038/s41429-022-00547-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A novel vicinal diepoxide of alloaureothin was isolated from Streptomyces sp. NIIST-D31 strain along with three carboxamides, p-aminobenzoic acid and 1,6-dimethoxyphenazine. Exhaustive 2D NMR analysis and analysis of experimental, theoretical CD spectra aided in establishing the structure of compound 1. Compound 1 inhibits adipogenesis and accumulation of lipid droplets during the differentiation of 3T3-L1 cells.
引用
收藏
页码：491 / 497
页数：7
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