Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

被引：358
作者：
Sonnweber, Thomas [1 ]
Pizzini, Alex [1 ]
Nairz, Manfred [1 ]
Weiss, Guenter [1 ]
Tancevski, Ivan [1 ]
机构：
[1] Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期
关键词：
arachidonic acid; eicosanoids; metabolic disease; obesity; nonalcoholic fatty liver disease; diabetes; atherosclerosis; cardiovascular disease; cholesterol; FATTY LIVER-DISEASE; SOLUBLE EPOXIDE HYDROLASE; RECEPTOR ANTAGONIST MONTELUKAST; ASPIRIN-TRIGGERED LIPOXIN; LEUKOTRIENE B-4 RECEPTOR; INSULIN-RESISTANCE; EPOXYEICOSATRIENOIC ACIDS; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; LIPID MEDIATORS;
D O I：
10.3390/ijms19113285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
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页数：26
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