Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

被引：323
作者：
Sonnweber, Thomas [1 ]
Pizzini, Alex [1 ]
Nairz, Manfred [1 ]
Weiss, Guenter [1 ]
Tancevski, Ivan [1 ]
机构：
[1] Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期
关键词：
arachidonic acid; eicosanoids; metabolic disease; obesity; nonalcoholic fatty liver disease; diabetes; atherosclerosis; cardiovascular disease; cholesterol; FATTY LIVER-DISEASE; SOLUBLE EPOXIDE HYDROLASE; RECEPTOR ANTAGONIST MONTELUKAST; ASPIRIN-TRIGGERED LIPOXIN; LEUKOTRIENE B-4 RECEPTOR; INSULIN-RESISTANCE; EPOXYEICOSATRIENOIC ACIDS; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; LIPID MEDIATORS;
D O I：
10.3390/ijms19113285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
引用
收藏
页数：26
相关论文
共 50 条
  • [21] Associations of ozone exposure with urinary metabolites of arachidonic acid
    He, Linchen
    Lin, Yan
    Wang, Xiangtian
    Liu, Xing
    Wang, Yang
    Qin, Jian
    Wang, Xiaoli
    Day, Drew
    Xiang, Jianbang
    Mo, Jinhan
    Zhang, Yinping
    Zhang, Junfeng
    ENVIRONMENT INTERNATIONAL, 2020, 145
  • [22] A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases
    Verma, Kanika
    Jain, Smita
    Paliwal, Swati
    Paliwal, Sarvesh
    Sharma, Swapnil
    CURRENT MOLECULAR PHARMACOLOGY, 2022, 15 (05) : 763 - 778
  • [23] Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats
    Alaeddine, Lynn M.
    Harb, Frederic
    Hamza, Maysaa
    Dia, Batoul
    Mogharbil, Nahed
    Azar, Nadim S.
    Noureldein, Mohamed H.
    El Khoury, Mirella
    Sabra, Ramzi
    Eid, Assaad A.
    TRANSLATIONAL RESEARCH, 2021, 235 : 85 - 101
  • [24] Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases
    Goettsch, Claudia
    Kjolby, Mads
    Aikawa, Elena
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38 (01) : 19 - 25
  • [25] Arachidonic acid metabolites in pathogenic yeasts
    Ruan Ells
    Johan LF Kock
    Jacobus Albertyn
    Carolina H Pohl
    Lipids in Health and Disease, 11
  • [26] Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases
    Hu, Yufeng
    Li, Wei
    Cheng, Xu
    Yang, Hailong
    She, Zhi-Gang
    Cai, Jingjing
    Li, Hongliang
    Zhang, Xiao-Jing
    CIRCULATION RESEARCH, 2024, 135 (01) : 222 - 260
  • [27] The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study
    Zhang, Ting
    Zhao, Jie, V
    Schooling, C. Mary
    EBIOMEDICINE, 2021, 63
  • [28] Arachidonic acid metabolites in pathogenic yeasts
    Ells, Ruan
    Kock, Johan L. F.
    Albertyn, Jacobus
    Pohl, Carolina H.
    LIPIDS IN HEALTH AND DISEASE, 2012, 11
  • [29] Managing metabolic diseases: The roles and therapeutic prospects of herb-derived polysaccharides
    Xu, Xinmei
    Wang, Lijie
    Zhang, Kun
    Zhang, Yi
    Fan, Gang
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 161
  • [30] Role of Arachidonic Acid and Its Metabolites in the Biological and Clinical Manifestations of Idiopathic Nephrotic Syndrome
    Turolo, Stefano
    Edefonti, Alberto
    Mazzocchi, Alessandra
    Syren, Marie Louise
    Morello, William
    Agostoni, Carlo
    Montini, Giovanni
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
12345