Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

被引：323
|
作者：
Sonnweber, Thomas [1 ]
Pizzini, Alex [1 ]
Nairz, Manfred [1 ]
Weiss, Guenter [1 ]
Tancevski, Ivan [1 ]
机构：
[1] Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期
关键词：
arachidonic acid; eicosanoids; metabolic disease; obesity; nonalcoholic fatty liver disease; diabetes; atherosclerosis; cardiovascular disease; cholesterol; FATTY LIVER-DISEASE; SOLUBLE EPOXIDE HYDROLASE; RECEPTOR ANTAGONIST MONTELUKAST; ASPIRIN-TRIGGERED LIPOXIN; LEUKOTRIENE B-4 RECEPTOR; INSULIN-RESISTANCE; EPOXYEICOSATRIENOIC ACIDS; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; LIPID MEDIATORS;
D O I：
10.3390/ijms19113285
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
引用
收藏
页数：26
相关论文
共 50 条
  • [1] Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
    Zhou, Yan
    Khan, Haroon
    Xiao, Jianbo
    Cheang, Wai San
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
  • [2] The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review
    Zhao, Cheng-Cheng
    Wu, Xin-Yue
    Yi, Huan
    Chen, Rong
    Fan, Gang
    CHEMISTRY & BIODIVERSITY, 2021, 18 (07)
  • [3] The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy
    Isse, Fadumo Ahmed
    El-Sherbeni, Ahmed A.
    El-Kadi, Ayman O. S.
    DRUG METABOLISM REVIEWS, 2022, 54 (02) : 141 - 160
  • [4] Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases
    Zordoky, Beshay N. M.
    El-Kadi, Ayman O. S.
    PHARMACOLOGY & THERAPEUTICS, 2010, 125 (03) : 446 - 463
  • [5] Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
    El Din, Usama A. A. Sharaf
    Salem, Mona M.
    Abdulazim, Dina O.
    JOURNAL OF ADVANCED RESEARCH, 2017, 8 (05) : 537 - 548
  • [6] Irisin in metabolic diseases
    Polyzos, Stergios A.
    Anastasilakis, Athanasios D.
    Efstathiadou, Zoe A.
    Makras, Polyzois
    Perakakis, Nikolaos
    Kountouras, Jannis
    Mantzoros, Christos S.
    ENDOCRINE, 2018, 59 (02) : 260 - 274
  • [7] Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases
    Stanzione, Rosita
    Forte, Maurizio
    Cotugno, Maria
    Bianchi, Franca
    Marchitti, Simona
    Busceti, Carla Letizia
    Fornai, Francesco
    Rubattu, Speranza
    CURRENT NEUROPHARMACOLOGY, 2022, 20 (04) : 662 - 674
  • [8] Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass
    Bosma, Karin J.
    Kaiser, Cecilia E.
    Kimple, Michelle E.
    Gannon, Maureen
    METABOLITES, 2022, 12 (04)
  • [9] Phospholipase A2 enzymes in metabolic and cardiovascular diseases
    Hui, David Y.
    CURRENT OPINION IN LIPIDOLOGY, 2012, 23 (03) : 235 - 240
  • [10] Implication of gut microbiota metabolites in cardiovascular and metabolic diseases
    Brial, Francois
    Le Lay, Aurelie
    Dumas, Marc-Emmanuel
    Gauguier, Dominique
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 75 (21) : 3977 - 3990
12345