A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

被引：88

作者：

Jurado, Sandra ^{[1
]}

Biou, Virginie ^{[1
,2
]}

Malenka, Robert C. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA

[2] Crucell Switzerland AG, Bern, Switzerland

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 09期

基金：

美国国家卫生研究院;

关键词：

AKAP SIGNALING COMPLEXES; AKAP150-ANCHORED PKA; AMPA RECEPTORS; DISTINCT; DYNAMICS; BINDING; SITE; LTD;

D O I：

10.1038/nn.2613

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin.

引用

页码：1053 / 1055

页数：3

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