Asymmetric synthesis of 4-aryl dihydroisoquinolin-3-ones and 2-aryl morpholin-3-ones using AgOTf-activated α-bromo arylacetate

被引：7

作者：

Hong, Su Kyung ^{[1
]}

Park, Wongi ^{[1
]}

Park, Yong Sun ^{[1
]}

机构：

[1] Konkuk Univ, Dept Chem, Seoul, South Korea

来源：

TETRAHEDRON | 2020年 / 76卷 / 04期

关键词：

Lactams; Dynamic resolution; Crystallization induced dynamic; Resolution; Friedel-Crafts alkylation; Asymmetric synthesis; ALKYLATION; DICLOFENSINE; SUBSTITUTION; PROTONATION; RESOLUTION; CHEMISTRY; BIOLOGY; DRUG;

D O I：

10.1016/j.tet.2019.130841

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel asymmetric synthetic strategy to prepare 4-aryl-dihydroisoquinolinones has been developed through a highly regioselective Friedel-Crafts alkylation of benzylamine derivatives with (alpha R)-alpha-bromo arylacetates and subsequent facile lactamization. In addition, an efficient asymmetric synthesis of 2-aryl morpholinones is demonstrated with 2-aminoethanol derivatives using the same convenient substitution-lactamization protocol. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：7

共 36 条

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