Stem Cells and Cancer Stem Cells: The Jekyll and Hyde Scenario and Their Implications in Stem Cell Therapy

被引：11
作者：
Zaman, Wan Safwani Wan Kamarul [1 ,2 ]
Nurul, Asma Abdullah [3 ]
Nordin, Fazlina [4 ]
机构：
[1] Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Engn, Ctr Innovat Med Engn CIME, Dept Biomed Engn, Kuala Lumpur 50603, Malaysia
[3] Univ Sains Malaysia, Sch Hlth Sci, Kubang Kerian 16150, Kelantan, Malaysia
[4] Univ Kebangsaan Malaysia, Med Ctr, Ctr Tissue Engn & Regenerat Med CTERM, Kuala Lumpur 56000, Malaysia
来源：
BIOMEDICINES | 2021年 / 9卷 / 09期
关键词：
stem cells; stem cell therapy; cancer stem cells; cancer cell; biosafety; bioefficacy; T-CELLS; DRUG-RESISTANCE; TUMOR; CD44; PROLIFERATION; FIBROBLASTS; EXOSOMES; PROMOTE; TUMORIGENESIS; MACROPHAGES;
D O I：
10.3390/biomedicines9091245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
"Jekyll and Hyde" refers to persons with an unpredictably dual personality, who are battling between good and evil within themselves In this regard, even cells consist of good and evil counterparts. Normal stem cells (NSCs) and cancer stem cells (CSCs) are two types of cells that share some similar characteristics but have distinct functions that play a major role in physiological and pathophysiological development. In reality, NSCs such as the adult and embryonic stem cells, are the good cells and the ultimate treatment used in cell therapy. CSCs are the corrupted cells that are a subpopulation of cancer cells within the cancer microenvironment that grow into a massive tumour or malignancy that needs to be treated. Hence, understanding the connection between NSCs and CSCs is important not just in cancer development but also in their therapeutic implication, which is the focus of this review.
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页数：17
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