miRNAs as Biomarkers for Diagnosing and Predicting Survival of Head and Neck Squamous Cell Carcinoma Patients

被引：35

作者：

Piotrowski, Igor ^{[1
,2
,3
]}

Zhu, Xiang ^{[3
]}

Saccon, Tatiana Dandolini ^{[4
]}

Ashiqueali, Sarah ^{[3
]}

Schneider, Augusto ^{[5
]}

Nunes, Allancer Divino de Carvalho ^{[3
]}

Noureddine, Sarah ^{[3
]}

Sobecka, Agnieszka ^{[1
,6
]}

Barczak, Wojciech ^{[1
,6
]}

Szewczyk, Mateusz ^{[6
,7
]}

Golusinski, Wojciech ^{[6
,7
]}

Masternak, Michal M. ^{[3
,6
]}

Golusinski, Pawel ^{[8
,9
]}

机构：

[1] Greater Poland Canc Ctr, Dept Med Phys, Radiobiol Lab, PL-61866 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Electroradiol, Ul Garbary 15, PL-61866 Poznan, Poland

[3] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA

[4] Univ Fed Pelotas, Ctr Desenvolvimento Tecnol, BR-96010610 Pelotas, RS, Brazil

[5] Univ Fed Pelotas, Fac Nutr, BR-96010610 Pelotas, RS, Brazil

[6] Poznan Univ Med Sci, Dept Head & Neck Surg, PL-61701 Poznan, Poland

[7] Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland

[8] Univ Zielona Gora, Dept Otolaryngol & Maxillofacial Surg, PL-65417 Zielona Gora, Poland

[9] Poznan Univ Med Sci, Dept Maxillofacial Surg, PL-61701 Poznan, Poland

来源：

CANCERS | 2021年 / 13卷 / 16期

关键词：

head and neck squamous cell carcinoma; oral cancer; oropharyngeal cancer; laryngeal cancer; miRNA; ORAL LICHEN-PLANUS; MICRORNA EXPRESSION; DOWN-REGULATION; SUPPRESSES; MIGRATION; INVASION; CANCER; GENE; PROLIFERATION; METAANALYSIS;

D O I：

10.3390/cancers13163980

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide. It arises from the epithelium of the upper aerodigestive tract. Increasing evidence suggests that there is a significant role of microRNAs in HNSCC formation and progression. The aim of this study was to explore and compare the expression of HNSCC related miRNAs in tumor vs neighboring healthy tissue of HNSCC patients with tumors located in either the oral cavity, oropharynx, or larynx. Our results demonstrated that expression of these miRNAs was significantly different not only between healthy and tumor tissues, but also among tumor locations. Further analysis indicated that microRNA expression could be used to distinguish between tumor and healthy tissues, and prognose the overall survival of patients. Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide. These tumors originate from epithelial cells of the upper aerodigestive tract. HNSCC tumors in different regions can have significantly different molecular characteristics. While many microRNAs (miRNAs) have been found to be involved in the regulation of the carcinogenesis and pathogenesis of HNSCC, new HNSCC related miRNAs are still being discovered. The aim of this study was to explore potential miRNA biomarkers that can be used to diagnose HNSCC and prognose survival of HNSCC patients. For this purpose, we chose a panel of 12 miRNAs: miR-146a-5p, miR-449a, miR-126-5p, miR-34a-5p, miR-34b-5p, miR-34c-5p, miR-217-5p, miR-378c, miR-6510-3p, miR-96-5p, miR-149-5p, and miR-133a-5p. Expression of these miRNAs was measured in tumor tissue and neighboring healthy tissue collected from patients diagnosed with HNSCC (n = 79) in either the oral cavity, oropharynx, or larynx. We observed a pattern of differentially expressed miRNAs at each of these cancer locations. Our study showed that some of these miRNAs, separately or in combination, could serve as biomarkers distinguishing between healthy and tumor tissue, and their expression correlated with patients' overall survival.

引用

页数：17

共 66 条

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