DNA double-strand break repair and development

被引：40
作者：
Phillips, E. R.
McKinnon, P. J.
机构：
[1] St Jude Childrens Hosp, Dept Genet & Tumor Cell Biol, Memphis, TN 38105 USA
[2] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA
来源：
ONCOGENE | 2007年 / 26卷 / 56期
关键词：
DNA repair; double-strand breaks; ATM; NHEJ; development;
D O I：
10.1038/sj.onc.1210877
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Normal development of an organism requires the ability to respond to DNA damage. A particularly deleterious lesion is a DNA double-strand break (DSB). The cellular response to DNA DSBs occurs via an integrated sensing and signaling network that maintains genomic stability. The outcomes of defective DNA DSB repair are related to the developmental stage of an organism, and often show striking tissue specificity. Many human diseases are associated with deficiencies in DNA DSB repair and can be characterized by neuropathology, immune deficiency, growth retardation or predisposition to cancer. This review will focus on the requirements of the DNA DSB response that function to maintain homeostasis during mammalian development.
引用
收藏
页码：7799 / 7808
页数：10
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