Antiallergic activities of rabdosiin and its related compounds: Chemical and biochemical evaluations

被引：75
作者：
Ito, H
Miyazaki, T
Ono, M
Sakurai, H
机构：
[1] Nagase & Co Ltd, Ctr Res & Dev, Kobe, Hyogo 6512241, Japan
[2] Kyoto Pharmaceut Univ, Dept Analyt Chem & Bioinorgan Chem, Yamashina Ku, Kyoto 6078841, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 07期
关键词：
rabdosiin; anti-allergic activity; ESR-spin trapping method; hyaluronidase; beta-hexosaminidase;
D O I：
10.1016/S0968-0896(98)00063-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined the effects of caffeic acid-containing compounds such as chlorogenic acid, rosmarinic acid and rabdosiin on anti-allergic activities involving active oxygens scavenging activity as well as inhibitory activities of hyaluronidase and beta-hexosaminidase release. Rabdosiin exhibited the highest hyaluronidase-inhibitory activity and scavenging activities against active oxygens species such as superoxide anion radicals and hydroxyl radicals among the tested compounds. Both rabdosiin and caffeic acid inhibited beta-hexosaminidase release from cultured cells more than 90% at 2 mM. The inhibition by rosmarinic acid and chlorogenic acid were weaker than that of rabdosiin. From these results, rabdosiin has been proposed to possess anti-allergic activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：1051 / 1056
页数：6
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