Two New Drimane Sesquiterpenoids from Compound Changweikang and Their Inhibitory Activity against Nitric Oxide Production

被引：6

作者：

Liu, Ming-sheng ^{[1
,2
]}

Liu, Chang ^{[3
]}

Zhang, Xiao-po ^{[1
]}

Sheng, Lin ^{[1
,2
]}

Zhang, Jun-qing ^{[1
,2
]}

Kang, Sheng-li ^{[1
,2
]}

机构：

[1] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571101, Peoples R China

[2] Hainan Prov Key Lab R&D Trop Herbs, Haikou 571101, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 09期

关键词：

compound Changweikang; Daphniphyllum calycinum; Polygonum hydropiper; changweikangic acid A; changweikangic acid B; nitric oxide production;

D O I：

10.1248/cpb.58.1224

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.

引用

页码：1224 / 1226

页数：3

共 7 条

[1] Polygodial, the fungitoxic component from the Brazilian medicinal plant Polygonum punctatum [J].

Alves, TMD ;

Ribeiro, FL ;

Kloos, H ;

Zani, CL .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2001, 96 (06) :831-833

[2]

Iijima T, 2003, CHEM PHARM BULL, V51, P545

[3]

[刘畅 LIU Chang], 2009, [中成药, Chinese Traditional Patent Medicine], V31, P1578

[4] Absolute stereostructures of polypodane- and octanordammarane-type triterpenes with nitric oxide production inhibitory activity from guggul-gum resins [J].

Matsuda, H ;

Morikawa, T ;

Ando, S ;

Oominami, H ;

Murakami, T ;

Kimura, I ;

Yoshikawa, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (11) :3037-3046

[5] Dendocarbins A-N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa [J].

Sakio, Y ;

Hirano, YJ ;

Hayashi, M ;

Komiyama, K ;

Ishibashi, M .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (06) :726-731

[6] Two new bis-coumarin glycosides from Daphne giraldii NITSCHE [J].

Su, Juan ;

Wu, Zhi-Jun ;

Zhang, Wei-Dong ;

Zhang, Chuan ;

Li, Hui-Liang ;

Liu, Run-Hui ;

Shen, Yun-Heng .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (04) :589-591

[7]

[谭银丰 TAN Yin-feng], 2009, [时珍国医国药, Lishizhen Medicine and Materia Medica Research], V20, P2941

← 1 →