SYNTHESIS AND NEUROTROPIC ACTIVITY OF 6-THIO-SUBSTITUTED PYRANO[3,4-c]PYRIDINE AND 1-AMINOPYRANO[4,3-d]-THIENO[2,3-b]PYRIDINE DERIVATIVES AND 9-SUBSTITUTED PYRIDO[2,3-b]THIENO[3,2-d]PYRIMIDINES

被引：7

作者：

Paronikyan, E. G. ^{[1
]}

Akopyan, Sh. F. ^{[1
]}

Noravyan, A. S. ^{[1
]}

Dzhagatspanyan, I. A. ^{[1
]}

Nazaryan, I. M. ^{[1
]}

Akopyan, A. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, AI Mndzhoyan Fine Organ Chem Inst, Yerevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 04期

关键词：

pyrano[3,4-c]pyridines; thieno[3,2-d]pyrimidines; neurotropic activity; anticonvulsive activity; diazepam; cyclization; condensation;

D O I：

10.1007/s11094-010-0426-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methods for the synthesis of condensed thieno[3,2-d]pyrimidines based on 3,3-dimethyl-8-morpholino-6-thioxo-3,4,6,7-tetrahydro-1H-pyrano[3,4-c]pyridine-5-y1 cyanide have been developed. The neurotropic properties of the synthesized compounds have been investigated. Compounds possessing anticonvulsant activity and sedative properties are found. These compounds also exhibit an activating effect that makes them analogous to the well-known drug diazepam.

引用

页码：183 / 185

页数：3

共 29 条

[1] Synthesis and neurotropic activity of 6-thio-substituted pyrano[3,4-c]pyridine and 1-aminopyrano[4,3-d]-thieno[2,3-b]pyridine derivatives and 9-substituted pyrido[2,3-b]thieno[3,2-d]pyrimidines
E. G. Paronikyan
Sh. F. Akopyan
A. S. Noravyan
I. A. Dzhagatspanyan
I. M. Nazaryan
A. G. Akopyan
Pharmaceutical Chemistry Journal, 2010, 44 : 183 - 185
[2] Synthesis of new condensed derivatives of pyrano[4,3-b]thieno[3,2-e]pyridine and pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
V. V. Dabaeva
M. R. Bagdasaryan
A. S. Noravyan
Chemistry of Heterocyclic Compounds, 2011, 47 : 639 - 643
[3] SYNTHESIS OF NEW CONDENSED DERIVATIVES OF PYRANO[4,3-b]THIENO[3,2-e]PYRIDINE AND PYRIDO[3′,2′:4,5]THIENO[3,2-d]PYRIMIDINE
Dabaeva, V. V.
Bagdasaryan, M. R.
Noravyan, A. S.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 47 (05) : 639 - 643
[4] Synthesis and Neurotropic Activity of New Pyrano[3,4-b]Furo[2,3-b]Pyridine Derivatives
Dabaeva, V. V.
Bagdasaryan, M. R.
Noravyan, A. S.
Kazaryan, Zh. V.
Dzhagatspanyan, I. A.
Nazaryan, I. M.
Akopyan, A. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2016, 49 (12) : 830 - 833
[5] Synthesis and Neurotropic Activity of New Pyrano[3,4-b]Furo[2,3-b]Pyridine Derivatives
V. V. Dabaeva
M. R. Bagdasaryan
A. S. Noravyan
Zh. V. Kazaryan
I. A. Dzhagatspanyan
I. M. Nazaryan
A. G. Akopyan
Pharmaceutical Chemistry Journal, 2016, 49 : 830 - 833
[6] Synthesis, Neurotropic Activity, and Molecular Docking of New Condensed Thieno[2,3-b]pyridine Derivatives
V. V. Dabaeva
M. R. Baghdasaryan
R. G. Paronikyan
I. M. Nazaryan
H. G. Hakobyan
L. S. Hunanyan
E. G. Paronikyan
Sh. Sh. Dashyan
Russian Journal of Bioorganic Chemistry, 2022, 48 : 125 - 134
[7] Synthesis, Neurotropic Activity, and Molecular Docking of New Condensed Thieno[2,3-b] pyridine Derivatives
Dabaeva, V. V.
Baghdasaryan, M. R.
Paronikyan, R. G.
Nazaryan, I. M.
Hakobyan, H. G.
Hunanyan, L. S.
Paronikyan, E. G.
Dashyan, Sh. Sh.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2022, 48 (01) : 125 - 134
[8] Synthesis of New Furo[2,3-b]pyridine and Furo[3,2-d]pyrimidine Derivatives
S. N. Sirakanyan
E. K. Hakobyan
A. A. Hovakimyan
Russian Journal of Organic Chemistry, 2019, 55 : 1344 - 1350
[9] Synthesis of New Furo[2,3-b]pyridine and Furo[3,2-d]pyrimidine Derivatives
Sirakanyan, S. N.
Hakobyan, E. K.
Hovakimyan, A. A.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 55 (09) : 1344 - 1350
[10] Synthesis and anticonvulsive activity of a series of new pyrano(thiopyrano,pyrido)-[4′,3′:4,5]thieno[2,3-d]pyrimidines
Mkrtchyan A.P.
Kazaryan S.G.
Noravyan A.S.
Dzhagatspanyan I.A.
Nazaryan I.M.
Akopyan A.G.
Pharmaceutical Chemistry Journal, 1998, 32 (9) : 469 - 473

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