The swinging lever-arm hypothesis of muscle contraction

被引：140

作者：

Holmes, KC

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(06)00051-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and bischemists for many years, The common View of the mechanism is embodied in the 'cross-bridge hypothesis', in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated muscle is brought about by the 'cross-bridges', parts of the myosin molecules which protrude from the thick filaments and interact cyclically with the actin filaments, transporting them by a rowing action that is powered by the hydrolysis of ATP, This hypothesis is, however, rather vague on the molecular details of cross-bridge movement and, in the light of the recently determined crystal structures of myosin and actin, it has evolved into the more precise 'swinging lever-arm hypothesis'.

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页码：R112 / R118

页数：7

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