A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers

被引：413
作者：
Lu, Kuangda [1 ]
He, Chunbai [1 ]
Lin, Wenbin [1 ]
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 24期
关键词：
IMMUNOGENIC CELL-DEATH; HIGHLY EFFICIENT; NANOPARTICLES; PORPHYRIN; DELIVERY; DRUGS;
D O I：
10.1021/jacs.5b04069
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report here the rational design of the first chlorin-based nanoscale Metal organic framework (NMOF), DBC-UiO, with Much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DC ligands in DBC-UiO led to a 13 fun red, shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystal, stability, porosity, and nanoplate morphology 61 DBP-UiO, DBC-UiO sensitizes more efficient O-1(2) generation and exhibits significantly enhanced photo, dynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its, improved photophysical properties. Both apoptosis and immunogenic tell death contributed to killing of cancer cells in DBC-UiO-induced PDT.
引用
收藏
页码：7600 / 7603
页数：4
相关论文
共 35 条
[1]   Photodynamic Therapy of Cancer: An Update [J].
Agostinis, Patrizia ;
Berg, Kristian ;
Cengel, Keith A. ;
Foster, Thomas H. ;
Girotti, Albert W. ;
Gollnick, Sandra O. ;
Hahn, Stephen M. ;
Hamblin, Michael R. ;
Juzeniene, Asta ;
Kessel, David ;
Korbelik, Mladen ;
Moan, Johan ;
Mroz, Pawel ;
Nowis, Dominika ;
Piette, Jacques ;
Wilson, Brian C. ;
Golab, Jakub .
CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) :250-281
[2]   Oncologic photodynamic therapy photosensitizers: A clinical review [J].
Allison, Ron R. ;
Sibata, Claudio H. .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75
[3]  
[Anonymous], BRATISLAVA MED J
[4]   NEW DRUGS AND FUTURE-DEVELOPMENTS IN PHOTODYNAMIC THERAPY [J].
ASH, DV ;
BROWN, SB .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (12) :1781-1783
[5]   Porphyrin-phospholipid liposomes permeabilized by near-infrared light [J].
Carter, Kevin A. ;
Shao, Shuai ;
Hoopes, Matthew I. ;
Luo, Dandan ;
Ahsan, Bilal ;
Grigoryants, Vladimir M. ;
Song, Wentao ;
Huang, Haoyuan ;
Zhang, Guojian ;
Pandey, Ravindra K. ;
Geng, Jumin ;
Pfeifer, Blaine A. ;
Scholes, Charles P. ;
Ortega, Joaquin ;
Karttunen, Mikko ;
Lovell, Jonathan F. .
NATURE COMMUNICATIONS, 2014, 5
[6]   Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].
Celli, Jonathan P. ;
Spring, Bryan Q. ;
Rizvi, Imran ;
Evans, Conor L. ;
Samkoe, Kimberley S. ;
Verma, Sarika ;
Pogue, Brian W. ;
Hasan, Tayyaba .
CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838
[7]   Nanoparticles in photodynamic therapy: An emerging paradigm [J].
Chatterjee, Dev Kumar ;
Fong, Li Shan ;
Zhang, Yong .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (15) :1627-1637
[8]   Functional Nanomaterials for Phototherapies of Cancer [J].
Cheng, Liang ;
Wang, Chao ;
Feng, Liangzhu ;
Yang, Kai ;
Liu, Zhuang .
CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939
[9]   Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer [J].
Cheng, Yu ;
Samia, Anna C. ;
Meyers, Joseph D. ;
Panagopoulos, Irene ;
Fei, Baowei ;
Burda, Clemens .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) :10643-10647
[10]   Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Drug Delivery [J].
Della Rocca, Joseph ;
Liu, Demin ;
Lin, Wenbin .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :957-968
1234