A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses

被引：41

作者：

Tort, Fernando L. ^{[1
]}

Castells, Matias ^{[1
]}

Cristina, Juan ^{[2
]}

机构：

[1] Univ Republ, Ctr Univ Reg, Sede Salto, Lab Virol Mol, Gral Rivera 1350, Salto 50000, Uruguay

[2] Univ Republica, Fac Ciencias, Ctr Invest Nucl, Lab Virol Mol, Igua 4225, Montevideo 11400, Uruguay

来源：

VIRUS RESEARCH | 2020年 / 283卷

关键词：

Coronavirus; Evolution; Codon usage; Wuhan; 2019-nCoV; SARS-CoV-2; NUCLEOTIDE COMPOSITION; BIAS; RNA; VIRUSES;

D O I：

10.1016/j.virusres.2020.197976

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An outbreak of atypical pneumonia caused by a novel Betacoronavirus (beta CoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of beta CoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.

引用

页数：7

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