Histamine and tumor necrosis factor-α production from purified rat brain mast cells mediated by substance P

被引：36
|
作者：
Cocchiara, R [1 ]
Albeggiani, G [1 ]
Lampiasi, N [1 ]
Bongiovanni, A [1 ]
Azzolina, A [1 ]
Geraci, D [1 ]
机构：
[1] CNR, Ist Biol Sviluppo, I-90146 Palermo, Italy
来源：
NEUROREPORT | 1999年 / 10卷 / 03期
关键词：
brain mast cells; histamine; substance P; TNF-alpha;
D O I：
10.1097/00001756-199902250-00024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE effect of cytokines and neuropeptides on neuroimmune functions has not been completely elucidated and recent evidence suggests an important role for these molecules linking the neuroimmune system and inflammatory events. The aim of this study was to analyse the effect of substance P (SP) on a pure population of hypothalamic brain mast cell (BMC). A pure population of BMC challenged with 10(-8) M SP gave 78% histamine release (HR) and secreted 600pg/ml of tumor necrosis factor-alpha (TNF-alpha) as determined by ELISA. The production of TNF-alpha mRNA, measured by a competitive RT-PCR, was 14 times higher than that in unstimulated cells. The secretion of histamine and TNF-alpha from BMC after stimulation with SP supports the hypothesis that these mediators could induce an initial response in neuroinflammatory diseases. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：575 / 578
页数：4
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