Amyotrophic lateral sclerosis - a multisystem neurodegenerative disorder

被引：19

作者：

Grossman, Murray ^{[1
,2
]}

机构：

[1] Univ Penn, Penn Frontotemporal Degenerat Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS NEUROLOGY | 2019年 / 15卷 / 01期

关键词：

PTDP-43; PATHOLOGY; PATTERNS;

D O I：

10.1038/s41582-018-0103-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis (ALS) is a progressive motor disorder, and many patients also show non-motor symptoms including executive, behavioural and language dysfunction. A new study demonstrates a robust relationship between progression of these non-motor symptoms and declining motor disease in patients with ALS, providing important insights into mechanisms of ALS pathogenesis.

引用

页码：5 / 6

页数：2

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