Light-Responsive Block Copolymer Micelles

被引：456

作者：

Zhao, Yue ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Chim, Sherbrooke, PQ J1K 2R1, Canada

来源：

MACROMOLECULES | 2012年 / 45卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

AMPHIPHILIC DIBLOCK COPOLYMERS; PHOTOLABILE PROTECTING GROUPS; CROSS-LINKED NANOGELS; NEAR-INFRARED LIGHT; SUPRAMOLECULAR ASSEMBLIES; HYDROPHOBIC ASSOCIATION; TRIGGERED DISSOCIATION; PHOTOINDUCED FUSION; AZOBENZENE MOIETIES; SIZE CHANGE;

D O I：

10.1021/ma300094t

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The association state of light-responsive block copolymer (BCP) micelles in aqueous solution can be altered, often reversibly, by light. Driven by the potential application in controlled drug delivery, this type of stimuli-responsive polymer micelles has received increasing attention. This Perspective highlights the progress achieved in recent years. On the one hand, we discuss the different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles. On the other hand, we suggest possible future directions in this area, including exploration of new mechanisms and chemistry and solutions to the excitation wavelength problem crucial for biomedical applications.

引用

页码：3647 / 3657

页数：11

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