Silver(I)- and Base-Mediated formal [4+3] Cycloaddition of in Situ generated 1,2-Diaza-1,3-dienes with C,N-Cyclic Azomethine Imines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives

被引：14
作者：
Li, Zefei [1 ]
Li, Shuaikang [1 ]
Kan, Tianjiao [1 ]
Wang, Xinyue [1 ]
Xin, Xin [1 ]
Hou, Yunlei [1 ]
Gong, Ping [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 13期
关键词：
Silver; 1,2-Diaza-1,3-dienes; Azomethine imines; 4+3] Cycloaddition; Tetrazepine derivatives; SILVER(I)-RHODIUM(I) COOPERATIVE CATALYSIS; INTERMOLECULAR 5+2 CYCLOADDITION; GAMMA-SUBSTITUENT ALLENOATES; ALPHA-HALOGENO HYDRAZONES; RING-CLOSURE REACTIONS; DIELS-ALDER REACTION; ASYMMETRIC-SYNTHESIS; 1,3-DIPOLAR CYCLOADDITIONS; TANDEM REACTION; SULFUR YLIDES;
D O I：
10.1002/adsc.202000398
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A silver(I)- and base-mediated formal [4+3] cycloaddition reaction of in situ generated 1,2-diaza-1,3-dienes with in situ formed C,N-cyclic azomethine imines has been developed. This protocol provided an efficient method for the synthesis of biologically important 1,2,4,5-tetrazepine derivatives with a wild substrate scope and excellent functional group tolerance in moderate to excellent yields.
引用
收藏
页码：2626 / 2631
页数：6
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