Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats

被引：152

作者：

Gobert, A ^{[1
]}

Millan, MJ ^{[1
]}

机构：

[1] Inst Rech Servier, Dept Psychopharmacol, F-78290 Paris, France

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 02期

关键词：

frontal cortex; 5-HT2C receptors; dopamine; noradrenaline;

D O I：

10.1016/S0028-3908(98)00188-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The 5HT(2) receptor agonist, DOI, dose-dependently (0.16-10.0 mg/kg, s.c.) increased dialysate levels of dopamine (DA) and noradrenaline (NA), but not 5-HT, in the frontal cortex (FCX) of freely-moving rats. This action was abolished by the selective 5-HT2A antagonist, MDL100,907 (0.04), which did not, itself, modify levels of DA and NA. In contrast, the selective 5-HT2B/2C antagonist, SB206,553 (0.63), increased levels of DA and NA additively with DOI. Thus, in contrast to a tonic, inhibitory influence of 5-HT2C receptors (see Millan, M.J., Dekeyne, A., Gobert, A., 1998. Serotonin (5-HT)(2C) receptors tonically inhibit dopamine (DA) and noradrenaline (NAD), but not 5-HT, release in the FCX in vivo. Neuropharmacology 37, 953-955), 5-HT2A receptors exert a phasic, facilitatory influence upon FCX levels of DA and NA. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：315 / 317

页数：3

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