Potential markers for detection of circulating canine mammary tumor cells in the peripheral blood

被引：23

作者：

da Costa, A. ^{[1
]}

Oliveira, J. T. ^{[2
]}

Gaertner, F. ^{[2
]}

Kohn, B. ^{[3
]}

Gruber, A. D. ^{[1
]}

Klopfleisch, R. ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Vet Pathol, D-14163 Berlin, Germany

[2] Univ Porto, Inst Mol Pathol & Immunol, P-4200456 Oporto, Portugal

[3] Free Univ Berlin, Small Anim Clin, D-14163 Berlin, Germany

来源：

VETERINARY JOURNAL | 2011年 / 190卷 / 01期

关键词：

Circulating tumor cells; Canine mammary tumors; Breast cancer; PCR; EXPRESSION;

D O I：

10.1016/j.tvjl.2010.09.027

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Major discrepancies exist between histological predictions and actual metastatic potential of canine mammary tumors. Detection of circulating tumor cells (CTC) has a proven prognostic value for human breast cancer but similar markers for canine CTC are lacking. In the present study a panel of 16 human CTC markers was tested for their ability to specifically and sensitively detect canine carcinoma cells in peripheral blood. PCR assays for CK19, ERBB2, EGFR, CLDN7 and ELF3 were able to sensitively detect one carcinoma cell in up to 10(7) peripheral blood leukocytes. These CTC markers are thus candidate markers for identifying canine mammary CTC in the peripheral blood and may serve as prognostic factors for metastatic behavior in the future. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：165 / 168

页数：4

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