Understanding obesity and endometrial cancer risk: opportunities for prevention

被引：156

作者：

Schmandt, Rosemarie E. ^{[1
]}

Iglesias, David A. ^{[1
]}

Co, Ngai Na ^{[1
]}

Lu, Karen H. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 205卷 / 06期

关键词：

endometrial cancer; estrogen; insulin; obesity; prevention; BODY-MASS-INDEX; ACTIVATED PROTEIN-KINASE; ESTROGEN-RECEPTOR-ALPHA; ORAL-CONTRACEPTIVE USE; SERUM SEX-HORMONES; PHYSICAL-ACTIVITY; POSTMENOPAUSAL WOMEN; BREAST-CANCER; INSULIN-RESISTANCE; ADIPOSE-TISSUE;

D O I：

10.1016/j.ajog.2011.05.042

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Worldwide, obesity has become a major public health crisis. Overweight and obesity not only increase the risk of cardiovascular disease and type-2 diabetes mellitus but also are now known risk factors for a variety of cancer types. Among all cancers, increasing body mass index is associated most strongly with endometrial cancer incidence and death. The molecular mechanisms underlying how adipose tissue and obesity contribute to the pathogenesis of endometrial cancer are becoming better understood and have revealed a number of rational strategies, both behavioral and pharmaceutical, for the prevention of both primary and recurrent disease.

引用

页码：518 / 525

页数：8

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