Neuroendocrine differentiation in follicle-cell thyroid carcinoma: Correlation to prognostic factors in papillary carcinoma

被引：0

作者：

Tseleni-Balafouta, S ^{[1
]}

Kavantzas, N ^{[1
]}

Alevizaki, M ^{[1
]}

Paraskevakou, H ^{[1
]}

Davaris, P ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Pathol, GR-10679 Athens, Greece

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 1998年 / 17卷 / 04期

关键词：

follicle-cell thyroid carcinoma; papillary thyroid carcinoma; prognosis;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of NE-differentiation in the follicle-cell thyroid carcinoma has been investigated by immunohistochemical detection of chromogranin A in the neoplastic cells. It has been found that NE-differentiation was present in a significant percentage in the papillary Ca alone (46.60%) whereas all Huerthle-cell neoplasms and the large majority of follicular and undifferentiated carcinomas showed non reactivity for Chromogranin A. Moreover, we have correlated the presence of NE-differentiation to well known prognostic factors in papillary Ca. We found a statistically significant correlation between the neuroendocrine differentiation and some unfavourable factors such as old age of the patient, size of the tumor, invasion of thyroid capsule and lymphnode involvement. We suggested that NE-differentiation could be considered as an index of poor prognosis.

引用

页码：533 / 537

页数：5

共 32 条

[1]

ABENOZA P, 1986, ARCH PATHOL LAB MED, V110, P1062

[2] THE COURSE OF NEURO-ENDOCRINE DIFFERENTIATION IN PROSTATIC CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY TESTING CHROMOGRANIN-A AS AN ENDOCRINE MARKER [J].

ABRAHAMSSON, PA ;

FALKMER, S ;

FALT, K ;

GRIMELIUS, L .

PATHOLOGY RESEARCH AND PRACTICE, 1989, 185 (03) :373-380

[3] MEDICAL-TREATMENT OF NEUROENDOCRINE TUMORS [J].

BAJETTA, E ;

DIBARTOLOMEO, M ;

ZILEMBO, N ;

BOCHICCHIO, AM .

TUMORI, 1993, 79 (06) :380-388

[4]

BARRETT RJ, 1987, CANCER, V60, P2325, DOI 10.1002/1097-0142(19871101)60:9<2325::AID-CNCR2820600935>3.0.CO

[5]

2-G

[6] A UNIQUE CELL-SURFACE PROTEIN PHENOTYPE DISTINGUISHES HUMAN SMALL-CELL FROM NON-SMALL-CELL LUNG-CANCER [J].

BAYLIN, SB ;

GAZDAR, AF ;

MINNA, JD ;

BERNAL, SD ;

SHAPER, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (15) :4650-4654

[7] THE PREVALENCE, PROGNOSTIC-SIGNIFICANCE AND HORMONAL CONTENT OF ENDOCRINE-CELLS IN GASTRIC-CANCER [J].

BONAR, SF ;

SWEENEY, EC .

HISTOPATHOLOGY, 1986, 10 (01) :53-63

[8] MULTIDIRECTIONAL DIFFERENTIATION IN THE NORMAL, HYPERPLASTIC, AND NEOPLASTIC HUMAN PROSTATE - SIMULTANEOUS DEMONSTRATION OF CELL-SPECIFIC EPITHELIAL MARKERS [J].

BONKHOFF, H ;

STEIN, U ;

REMBERGER, K .

HUMAN PATHOLOGY, 1994, 25 (01) :42-46

[9]

Carcangiu M L, 1985, Pathol Annu, V20 Pt 1, P1

[10] DIFFUSE SCLEROSING VARIANT OF PAPILLARY THYROID-CARCINOMA - CLINICOPATHOLOGIC STUDY OF 15 CASES [J].

CARCANGIU, ML ;

BIANCHI, S .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1989, 13 (12) :1041-1049

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