Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity

被引：3
|
作者：
Hegazy, GH [1 ]
Taher, A
El-Zaher, AA
机构：
[1] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
来源：
ARCHIV DER PHARMAZIE | 2005年 / 338卷 / 08期
关键词：
floctafenine; esters; antipyrine; anti-inflammatory/analgesic activity;
D O I：
10.1002/ardp.200400959
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the P-benzoquinone-induced writhing test in mice.
引用
收藏
页码：378 / 384
页数：7
相关论文
共 50 条
  • [31] Synthesis, anti-inflammatory and analgesic activity screening of some new 4(3H)-quinazolinone derivatives
    Yesilada, A
    Koyunoglu, S
    Saygili, N
    Kupeli, E
    Yesilada, E
    Bedir, E
    Khan, I
    ARCHIV DER PHARMAZIE, 2004, 337 (02) : 96 - 104
  • [32] Synthesis, Anti-inflammatory, Analgesic, and Antibacterial Activities of Some Triazole, Triazolothiadiazole, and Triazolothiadiazine Derivatives
    Hussein, Mostafa A.
    Shaker, Refaat M.
    Ameen, Mohammed A.
    Mohammed, Mohammed F.
    ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (08) : 1239 - 1250
  • [33] Synthesis, anti-inflammatory, analgesic, and antibacterial activities of some triazole, triazolothiadiazole, and triazolothiadiazine derivatives
    Mostafa A. Hussein
    Refaat M. Shaker
    Mohammed A. Ameen
    Mohammed F. Mohammed
    Archives of Pharmacal Research, 2011, 34 : 1239 - 1250
  • [34] Synthesis and analgesic and anti-inflammatory activity of new pyridazinones
    Dogruer, DS
    Sahin, MF
    Küpeli, E
    Yesilada, E
    TURKISH JOURNAL OF CHEMISTRY, 2003, 27 (06): : 727 - 738
  • [35] A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
    Battilocchio, Claudio
    Poce, Giovanna
    Alfonso, Salvatore
    Porretta, Giulio Cesare
    Consalvi, Sara
    Sautebin, Lidia
    Pace, Simona
    Rossi, Antonietta
    Ghelardini, Carla
    Mannelli, Lorenzo Di Cesare
    Schenone, Silvia
    Giordani, Antonio
    Di Francesco, Luigia
    Patrignani, Paola
    Biava, Mariangela
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (13) : 3695 - 3701
  • [36] Novel Thiazolotriazolone Derivatives: Design, Synthesis, In Silico Investigation, Analgesic and Anti-inflammatory Activity
    Almasirad, Ali
    Sani, Parvane Sadat Vafaei
    Mousavi, Zahra
    Fard, Gholamreza Behnami
    Anvari, Taha
    Farhadi, Maryam
    Vosooghi, Mohsen
    Azizian, Homa
    CHEMISTRYSELECT, 2022, 7 (28):
  • [37] ANTI-INFLAMMATORY ACTIVITY OF SOME DERIVATIVES OF SULFOLAN
    KAMALOVA, EG
    DAVYDOVA, VA
    LAZAREVA, DN
    TOLSTIKOV, GA
    NOVITSKAYA, NN
    FLEKTER, BV
    FARMAKOLOGIYA I TOKSIKOLOGIYA, 1979, 42 (03): : 261 - 265
  • [38] Synthesis of New Visnagen and Khellin Furochromone Pyrimidine Derivatives and Their Anti-Inflammatory and Analgesic Activity
    Abu-Hashem, Ameen Ali
    Youssef, Mohamed M.
    MOLECULES, 2011, 16 (03) : 1956 - 1972
  • [39] Naproxenylamino acid derivatives: Design, synthesis, docking, QSAR and anti-inflammatory and analgesic activity
    Elhenawy, Ahmed A.
    AL-Harbi, L. M.
    El-Gazzar, M. A.
    Khowdiary, Manal M.
    Ouidate, Adnane
    Alosaimi, Abeer M.
    Salim, Abd Elhamid
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 116
  • [40] Synthesis of sulpha drug acridine derivatives and their evaluation for anti-inflammatory, analgesic and anticancer activity
    Sondhi, SM
    Johar, M
    Singh, N
    Shukla, R
    Raghubir, R
    Dastidar, SG
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2002, 41 (12): : 2659 - 2666
12345