The effect of age and dose number on the risk of collapse (hypotonic-hyporesponsive episode) after pertussis vaccination

被引：6

作者：

Bondt, Patricia E. Vermeer-de ^{[1
]}

van der Maas, Nicoline A. T. ^{[1
]}

机构：

[1] RIVM, Natl Vaccinat Programme, Safety Surveillance & Consultat Serv, Bilthoven, Netherlands

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 04期

关键词：

adverse event following immunization (AEFI); collapse; hypotonic-hyporesponsive episode; pertussis vaccine;

D O I：

10.1097/INF.0b013e318162a127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Netherlands vaccination schedule has been advanced by I month. The reporting rate of collapse or hypotonic-hyporesponsive episode increased from 5.2 [95% confidence interval (CI): 4.8-5.7] to 8.5 (95% CI: 8.0-9.1) and from 1.2 (95% CI: 1.0-1.4) to 2.5 (95% CI: 2.2-2.8) per 10,000 first and second doses, respectively. At 3 months of age it fell from 5.2 to 2.5. This suggests some protection by the first dose. Different mediators in primary and secondary immune response may play a role.

引用

页码：355 / 357

页数：3

共 15 条

[1]

BLUMBERG DA, 1991, DEV BIOLOGICALS, V73, P289

[2] Hypotonic-Hyporesponsive Episode (HHE) as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation [J].

Bonhoeffer, J ;

Gold, MS ;

Heijbel, H ;

Vermeer, P ;

Blumberg, D ;

Braun, M ;

de Souza-Brito, G ;

Davis, RL ;

Halperin, S ;

Heininger, U ;

Khuri-Bulos, N ;

Menkes, J ;

Nokleby, H .

VACCINE, 2004, 22 (5-6) :563-568

[3] Report of a US Public Health Service Workshop on hypotonic-hyporesponsive episode (HHE) after pertussis immunization [J].

Braun, MM ;

Terracciano, G ;

Salive, ME ;

Blumberg, DA ;

Vermeer-de Bondt, PE ;

Heijbel, H ;

Evans, G ;

Patriarca, PA ;

Ellenberg, SS .

PEDIATRICS, 1998, 102 (05)

[4] Hypotonic-hyporesponsive episode (HHE) as an adverse event following immunization in early childhood: Case definition and guidelines for data collection, analysis, and presentation [J].

Buettcher, Michael ;

Heininger, Ulrich ;

Braun, Miles ;

Bonhoeffer, Jan ;

Halperin, Scott ;

Heijbel, Harald ;

Martins, Reinaldo de Menezes ;

Vermeer-de Bondt, Patricia .

VACCINE, 2007, 25 (31) :5875-5881

[5]

CODY CL, 1981, PEDIATRICS, V68, P650

[6]

HANNIK CA, 1979, P 3 INT S PERT BETHS, V79, P279

[7]

Heijbel H, 1997, DEV BIOL STAND, V89, P101

[8]

MAASVANDER N, IN PRESS NED TIJDSCH

[9]

MAASVANDER N, 2006, ADVERSE EVENTS FOLLO

[10]

RUMKE HC, 1999, TIJDSCHR JEUGDGEZOND, V31, P2

← 1 2 →