共 16 条
A Myriad of Symptoms After Spinal Anesthesia: A Case Report of Local Anesthetic Systemic Toxicity
被引:2
作者:

Lavado, Pedro
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal

Carvalho, Eduardo
论文数: 0 引用数: 0
h-index: 0
机构:
North Alentejo Local Hlth Unit, Intens Care Unit, Portalegre, Portugal Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal

Almeida, Manuel
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal

Taveira, Isabel
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal

Padua, Fernando
论文数: 0 引用数: 0
h-index: 0
机构:
North Alentejo Local Hlth Unit, Intens Care Unit, Portalegre, Portugal Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal
机构:
[1] Ctr Hosp Univ Algarve, Intens Care Unit, Portimao, Portugal
[2] North Alentejo Local Hlth Unit, Intens Care Unit, Portalegre, Portugal
关键词:
last;
spinal anesthesia;
seizure;
toxicity;
local anesthetic;
cardiac arrest;
LIPID EMULSION;
BUPIVACAINE;
D O I:
10.7759/cureus.29902
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Local anesthetics are widely used by various medical professionals. Although their usefulness is unquestionable, as with any medication, there is a possibility of iatrogenic effects. When local anesthetic systemic toxicity occurs, it might be a life-threatening condition. Knowing its existence and how to act when it arises is crucial. The clinical presentation is wide-ranging, but globally it affects the neurological and cardiovascular system, with cardiac arrest being the extreme of its presentation. The treatment is mainly supportive with an attempt to reverse the effects of the anesthetic by administering a lipid emulsion. Here, we present a clinical case of difficult management with many complications.
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共 16 条
[1]
TOXICITY OF LOCAL-ANESTHETICS
[J].
ALPER, MH
.
NEW ENGLAND JOURNAL OF MEDICINE,
1976, 295 (25)
:1432-1433

ALPER, MH
论文数: 0 引用数: 0
h-index: 0
机构:
BOSTON HOSP WOMEN,BOSTON,MA 02115 BOSTON HOSP WOMEN,BOSTON,MA 02115
[2]
ACMT Position Statement: Guidance for the Use of Intravenous Lipid Emulsion
[J].
American College of Medical Toxicology
.
Journal of Medical Toxicology,
2017, 13 (1)
:124-125

American College of Medical Toxicology
论文数: 0 引用数: 0
h-index: 0
机构: ACMT,
[3]
A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers
[J].
Bardsley, H
;
Gristwood, R
;
Baker, H
;
Watson, N
;
Nimmo, W
.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY,
1998, 46 (03)
:245-249

Bardsley, H
论文数: 0 引用数: 0
h-index: 0
机构: Chirosci Ltd, Cambridge CB4 4WE, England

Gristwood, R
论文数: 0 引用数: 0
h-index: 0
机构: Chirosci Ltd, Cambridge CB4 4WE, England

Baker, H
论文数: 0 引用数: 0
h-index: 0
机构: Chirosci Ltd, Cambridge CB4 4WE, England

Watson, N
论文数: 0 引用数: 0
h-index: 0
机构: Chirosci Ltd, Cambridge CB4 4WE, England

Nimmo, W
论文数: 0 引用数: 0
h-index: 0
机构: Chirosci Ltd, Cambridge CB4 4WE, England
[4]
Clinical Presentation of Local Anesthetic Systemic Toxicity A Review of Published Cases, 1979 to 2009
[J].
Di Gregorio, Guido
;
Neal, Joseph M.
;
Rosenquist, Richard W.
;
Weinberg, Guy L.
.
REGIONAL ANESTHESIA AND PAIN MEDICINE,
2010, 35 (02)
:181-187

Di Gregorio, Guido
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmacol & Anaesthesiol, I-35100 Padua, Italy Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Neal, Joseph M.
论文数: 0 引用数: 0
h-index: 0
机构:
Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Rosenquist, Richard W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Anesthesiol, Iowa City, IA USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Weinberg, Guy L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown VA Med Ctr, Chicago, IL USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
[5]
Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion
[J].
Fettiplace, Michael R.
;
Lis, Kinga
;
Ripper, Richard
;
Kowal, Katarzyna
;
Pichurko, Adrian
;
Vitello, Dominic
;
Rubinstein, Israel
;
Schwartz, David
;
Akpa, Belinda S.
;
Weinberg, Guy
.
JOURNAL OF CONTROLLED RELEASE,
2015, 198
:62-70

Fettiplace, Michael R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Lis, Kinga
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Ripper, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Kowal, Katarzyna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Pichurko, Adrian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Vitello, Dominic
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Rubinstein, Israel
论文数: 0 引用数: 0
h-index: 0
机构:
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA
Univ Illinois, Coll Dent, Dept Med, Sect Pulm Crit Care Sleep & Allergy Med, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Schwartz, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Akpa, Belinda S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Chem Engn, Chicago, IL 60607 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA

Weinberg, Guy
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
Jesse Brown Vet Affairs Med Ctr, Res & Dev Serv, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Anesthesiol, Chicago, IL 60612 USA
[6]
The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels
[J].
Gao, YaNan
;
Chen, Bo
;
Zhang, Xue
;
Yang, Rui
;
Hua, QingLi
;
Li, BaiDong
.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,
2020, 48 (08)

Gao, YaNan
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China

Chen, Bo
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, ICU, Daqing, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China

Zhang, Xue
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, ICU, Daqing, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China

Yang, Rui
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, Cardiothorac Surg Dept, Daqing, Peoples R China
Daqing Longnan Hosp, Cardiothorac Surg Dept, 35 Aiguo Rd, Daqing City 163001, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China

Hua, QingLi
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China

Li, BaiDong
论文数: 0 引用数: 0
h-index: 0
机构:
Daqing Longnan Hosp, Cardiothorac Surg Dept, Daqing, Peoples R China
Daqing Longnan Hosp, Cardiothorac Surg Dept, 35 Aiguo Rd, Daqing City 163001, Peoples R China Daqing Longnan Hosp, Anesthesiol Dept, Daqing, Peoples R China
[7]
Local anesthetics
[J].
Heavner, James E.
.
CURRENT OPINION IN ANESTHESIOLOGY,
2007, 20 (04)
:336-342

Heavner, James E.
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Tech Univ, Hlth Sci Ctr, Dept Anesthesiol & Physiol, Lubbock, TX 79430 USA Texas Tech Univ, Hlth Sci Ctr, Dept Anesthesiol & Physiol, Lubbock, TX 79430 USA
[8]
Lipid Emulsion Increases the Fast Na+ Current and Reverses the Bupivacaine-induced Block: A New Aspect of Lipid Resuscitation?
[J].
Hori, Kotaro
;
Kuno, Miyuki
;
Nishikawa, Kiyonobu
.
ANESTHESIOLOGY,
2014, 121 (04)
:903-904

Hori, Kotaro
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka City Univ, Grad Sch Med, Osaka 558, Japan Osaka City Univ, Grad Sch Med, Osaka 558, Japan

Kuno, Miyuki
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka City Univ, Grad Sch Med, Osaka 558, Japan Osaka City Univ, Grad Sch Med, Osaka 558, Japan

Nishikawa, Kiyonobu
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka City Univ, Grad Sch Med, Osaka 558, Japan Osaka City Univ, Grad Sch Med, Osaka 558, Japan
[9]
Incidence of Local Anesthetic Systemic Toxicity in Orthopedic Patients Receiving Peripheral Nerve Blocks
[J].
Morwald, Eva E.
;
Zubizarreta, Nicole
;
Cozowicz, Crispiana
;
Poeran, Jashvant
;
Memtsoudis, Stavros G.
.
REGIONAL ANESTHESIA AND PAIN MEDICINE,
2017, 42 (04)
:442-445

Morwald, Eva E.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA
Paracelsus Med Univ, Perioperat Med & Intens Care Med, Salzburg, Austria Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA

Zubizarreta, Nicole
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Inst Healthcare Delivery Sci, New York, NY 10029 USA Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA

Cozowicz, Crispiana
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA
Paracelsus Med Univ, Perioperat Med & Intens Care Med, Salzburg, Austria Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA

Poeran, Jashvant
论文数: 0 引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Inst Healthcare Delivery Sci, New York, NY 10029 USA Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA

Memtsoudis, Stavros G.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA Hosp Special Surg, Weill Cornell Med Coll New York, Dept Anesthesiol, 535 E 70th St, New York, NY 10021 USA
[10]
The American Society of Regional Anesthesia and Pain Medicine Checklist for Managing Local Anesthetic Systemic Toxicity: 2017 Version
[J].
Neal, Joseph M.
;
Woodward, Crystal M.
;
Harrison, T. Kyle
.
REGIONAL ANESTHESIA AND PAIN MEDICINE,
2018, 43 (02)
:150-153

Neal, Joseph M.
论文数: 0 引用数: 0
h-index: 0
机构:
Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA

Woodward, Crystal M.
论文数: 0 引用数: 0
h-index: 0
机构:
Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA

Harrison, T. Kyle
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Anesthesiol, Palo Alto, CA 94304 USA Virginia Mason Med Ctr, Dept Anesthesiol, Seattle, WA 98101 USA