Neuronal damage and its relation to dementia in acquired immunodeficiency syndrome (AIDS)

被引：9

作者：

TrilloPazos, G

Everall, IP

机构：

[1] INST PSYCHIAT,DEPT NEUROPATHOL,LONDON SE5 8AF,ENGLAND

[2] INST PSYCHIAT,DEPT MED PSYCHOL,LONDON SE5 8AF,ENGLAND

来源：

PATHOBIOLOGY | 1996年 / 64卷 / 06期

关键词：

HIV-associated dementia; AIDS; neuronal loss; HIV proteins; gp120; kat; nef; cytokines;

D O I：

10.1159/000164064

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are an estimated 21.8 million people infected with human immunodeficiency virus (HIV) worldwide [Weekly Epidemiol Rec 1996;27:204-208] and 90% of these people will have some form of neuropathological abnormality during the course of acquired immunodeficiency syndrome (AIDS). In this review, we will highlight the primary HIV-associated brain disorders. The role of HIV proteins and cytokines on neuronal damage will be assessed. We will also discuss the role of neuronal loss and functional damage in HIV-associated dementia.

引用

页码：295 / 307

页数：13

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