Organocatalytic Asymmetric Biomimetic Transamination: From α-Keto Esters to Optically Active α-Amino Acid Derivatives

被引：122

作者：

Xiao, Xiao ^{[1
]}

Xie, Ying ^{[1
]}

Su, Cunxiang ^{[1
]}

Liu, Mao ^{[1
]}

Shi, Yin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

[2] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 33期

关键词：

PHASE-TRANSFER CATALYSIS; ENANTIOSELECTIVE REDUCTIVE AMINATION; IMINO ESTERS; NONENZYMATIC TRANSAMINATION; TRANSFER HYDROGENATION; CINCHONA ALKALOIDS; ELECTROPHILIC SUBSTITUTION; ENANTIOMERIC EXCESSES; CONJUGATE ADDITION; PHOSPHORUS LIGANDS;

D O I：

10.1021/ja203138q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper describes an effective chiral base-catalyzed biomimetic transamination of a-keto esters using simple benzyl amines. A wide variety of a.-amino esters containing various functional groups can be synthesized in high enantioselectivity and reasonable yield.

引用

页码：12914 / 12917

页数：4