COVID-19 triggering mucormycosis in a susceptible patient: a new phenomenon in the developing world?

被引:147
作者
Revannavar, Shweta Mallikarjun [1 ]
Supriya, P. S. [1 ]
Samaga, Laxminarayana [1 ]
Vineeth, V. K. [1 ]
机构
[1] Nitte Univ, Gen Med, KS Hegde Med Acad, Mangalore, Karnataka, India
关键词
COVID-19; diabetes; tropical medicine (infectious disease); stroke;
D O I
10.1136/bcr-2021-241663
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A middle-aged woman with diabetes presented with left-sided facial pain, complete ptosis and fever of short duration. On presentation, she had hyperglycaemia without ketosis. There was total ophthalmoplegia of the left eye with a visual acuity of 6/36. She incidentally tested positive for COVID-19. CT paranasal sinus and MRI brain revealed left-sided pansinusitis with acute infarct in the left parieto-occipital region without angioinvasion. An emergency functional endoscopic sinus procedure was done, which confirmed mucormycosis on histopathological examination. After 1 week of conventional amphotericin B and antibiotics, repeat CT brain showed improvement in mucosal thickening and sinusitis. This case is a rare presentation of mucormycosis associated with rapid progression to orbital apex syndrome with brain infarction in a patient with non-ketotic diabetes and COVID-19. Early diagnosis and treatment are essential to prevent further end-organ damage. It is also interesting that there was no angioinvasion and transient periarterial inflammation was attributed to brain infarction.
引用
收藏
页数:4
相关论文
共 11 条
[1]   Diabetes, infection risk and COVID-19 [J].
Erener, Suheda .
MOLECULAR METABOLISM, 2020, 39
[2]   The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports [J].
Jeong, W. ;
Keighley, C. ;
Wolfe, R. ;
Lee, W. L. ;
Slavin, M. A. ;
Kong, D. C. M. ;
Chen, S. C. -A. .
CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (01) :26-34
[3]   Rhino-Orbital Mucormycosis Associated With COVID-19 [J].
Mehta, Salil ;
Pandey, Abha .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (09)
[4]   Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome [J].
Mekonnen, Zesemayat K. ;
Ashraf, Davin C. ;
Jankowski, Tyler ;
Grob, Seanna R. ;
Vagefi, M. Reza ;
Kersten, Robert C. ;
Simko, Jeffry P. ;
Winn, Bryan J. .
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2021, 37 (02) :E40-E42
[5]   A challenging complication following SARS-CoV-2 infection: a case of pulmonary mucormycosis [J].
Pasero, Daniela ;
Sanna, Silvana ;
Liperi, Corrado ;
Piredda, Davide ;
Branca, Gian Pietro ;
Casadio, Lorenzo ;
Simeo, Raffaella ;
Buselli, Alice ;
Rizzo, Davide ;
Bussu, Francesco ;
Rubino, Salvatore ;
Terragni, Pierpaolo .
INFECTION, 2021, 49 (05) :1055-1060
[6]   Global Epidemiology of Mucormycosis [J].
Prakash, Hariprasath ;
Chakrabarti, Arunaloke .
JOURNAL OF FUNGI, 2019, 5 (01)
[7]   COVID-19 and rhinology, from the consultation room to the operating theatre [J].
Radulesco, T. ;
Verillaud, B. ;
Bequignon, E. ;
Papon, J. -F. ;
Jankowski, R. ;
De Gabory, L. Le Taillandier ;
Dessi, P. ;
Coste, A. ;
Serrano, E. ;
Vergez, S. ;
Simon, F. ;
Couloigner, V. ;
Rumeau, C. ;
Michel, J. .
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES, 2020, 137 (04) :309-314
[8]   Mucor in a Viral Land: A Tale of Two Pathogens [J].
Sen, Mrittika ;
Lahane, Sumeet ;
Lahane, Tatyarao P. ;
Parekh, Ragini ;
Honavar, Santosh G. .
INDIAN JOURNAL OF OPHTHALMOLOGY, 2021, 69 (02) :244-252
[9]   Epidemiology and Diagnosis of Mucormycosis: An Update [J].
Skiada, Anna ;
Pavleas, Ioannis ;
Drogari-Apiranthitou, Maria .
JOURNAL OF FUNGI, 2020, 6 (04) :1-20
[10]   A Case of Fatal Rhino-Orbital Mucormycosis Associated With New Onset Diabetic Ketoacidosis and COVID-19 [J].
Waizel-Haiat, Salomon ;
Alberto Guerrero-Paz, Jose ;
Sanchez-Hurtado, Luis ;
Calleja-Alarcon, Salvador ;
Romero-Gutierrez, Laura .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (02)