CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes

被引：145

作者：

Edelson, Brian T. ^{[1
]}

Bradstreet, Tara R. ^{[1
]}

Hildner, Kai ^{[1
,2
]}

Carrero, Javier A. ^{[1
]}

Frederick, Katherine E. ^{[1
]}

Wumesh, K. C. ^{[1
]}

Belizaire, Roger ^{[1
]}

Aoshi, Taiki ^{[1
]}

Schreiber, Robert D. ^{[1
]}

Miller, Mark J. ^{[1
]}

Murphy, Theresa L. ^{[1
]}

Unanue, Emil R. ^{[1
]}

Murphy, Kenneth M. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

IMMUNITY | 2011年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; IN-VIVO; SPLENECTOMIZED MICE; PROTECTIVE IMMUNITY; MONOCLONAL-ANTIBODY; MOUSE SPLEEN; RESISTANCE; ACTIVATION; SUBSET; LYMPHOCYTES;

D O I：

10.1016/j.immuni.2011.06.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 alpha(+) dendritic cells (DCs) prime cytotoxic T lymphocytes during viral infections and produce interleukin-12 in response to pathogens. Although the loss of CD8 alpha(+) DCs in Batf3(-/-) mice increases their susceptibility to several pathogens, we observed that Batf3(-/-) mice exhibited enhanced resistance to the intracellular bacterium Listeria monocytogenes. In wild-type mice, Listeria organisms, initially located in the splenic marginal zone, migrated to the periarteriolar lymphoid sheath (PALS) where they grew exponentially and induced widespread lymphocyte apoptosis. In Batf3(-/-) mice, however, Listeria organisms remain trapped in the marginal zone, failed to traffic into the PALS, and were rapidly cleared by phagocytes. In addition, Batf3(-/-) mice, which lacked the normal population of hepatic CD103(+) peripheral DCs, also showed protection from liver infection. These results suggest that Batf3-dependent CD8 alpha(+) and CD103(+) DCs provide initial cellular entry points within the reticuloendothelial system by which Listeria establishes productive infection.

引用

页码：236 / 248

页数：13

共 51 条

[51] Dynamic Imaging of the Effector Immune Response to Listeria Infection In Vivo [J].

Waite, Janelle C. ;

Leiner, Ingrid ;

Lauer, Peter ;

Rae, Chris S. ;

Barbet, Gaetan ;

Zheng, Huan ;

Portnoy, Daniel A. ;

Pamer, Eric G. ;

Dustin, Michael L. .

PLOS PATHOGENS, 2011, 7 (03)

← 1 2 3 4 5 6 →