CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin

被引:25
作者
Osborne, TF [1 ]
机构
[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
关键词
D O I
10.1101/gad.916601
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:1873 / 1878
页数:6
相关论文
共 43 条
  • [1] Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
    Amemiya-Kudo, M
    Shimano, H
    Yoshikawa, T
    Yahagi, N
    Hasty, AH
    Okazaki, H
    Tamura, Y
    Shionoiri, F
    Iizuka, Y
    Ohashi, K
    Osuga, J
    Harada, K
    Gotoda, T
    Sato, R
    Kimura, S
    Ishibashi, S
    Yamada, N
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (40) : 31078 - 31085
  • [2] Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein
    Athanikar, JN
    Osborne, TF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) : 4935 - 4940
  • [3] A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    Brown, MS
    Goldstein, JL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) : 11041 - 11048
  • [4] BROWN MS, 1980, J LIPID RES, V21, P505
  • [5] Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
    DeBose-Boyd, RA
    Ou, JF
    Goldstein, JL
    Brown, MS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) : 1477 - 1482
  • [6] Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2
    Duncan, EA
    Brown, MS
    Goldstein, JL
    Sakai, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (19) : 12778 - 12785
  • [7] Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning
    Duncan, EA
    Davé, UP
    Sakai, J
    Goldstein, JL
    Brown, MS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (28) : 17801 - 17809
  • [8] Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway
    Edwards, PA
    Ericsson, J
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 : 157 - 185
  • [9] Regulation of gene expression by SREBP and SCAP
    Edwards, PA
    Tabor, D
    Kast, HR
    Venkateswaran, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1529 (1-3): : 103 - 113
  • [10] MEMBRANE-BOUND DOMAIN OF HMG COA REDUCTASE IS REQUIRED FOR STEROL-ENHANCED DEGRADATION OF THE ENZYME
    GIL, G
    FAUST, JR
    CHIN, DJ
    GOLDSTEIN, JL
    BROWN, MS
    [J]. CELL, 1985, 41 (01) : 249 - 258