New optical reference standard in the field of biology: interrogation of micro-resonator based biosensor with a Phase Sensitive-Optical Low Coherence Interferometer

A phase-sensitive optical low coherence interferometer is investigated experimentally to implement a new optical reference standard in the field of biology. This interrogation technique is associated to a planar cyclic resonant sensor such as an optical waveguide-based micro-cavity. The biological solution to be analyzed will be brought onto the surface of the sensor through a micro-fluidic cell. The aim of this association is to quantify low concentrations of analytes and to realize a real-time investigation of the kinetics of specific molecules with time and temperature for metrological applications, with better sensitivity and accuracy than existing techniques. This paper deals with the results of a feasibility study on the PS-OLCI technique as a new reference in the field of biology.