Targeting Age-Related Pathways in Heart Failure

被引：162
作者：
Li Haobo [1 ]
Hastings, Margaret H. [1 ]
Rhee, James [1 ,2 ]
Trager, Lena E. [1 ]
Roh, Jason D. [1 ]
Rosenzweig, Anthony [1 ]
机构：
[1] Harvard Med Sch, Corrigan Minehan Heart Ctr, Massachusetts Gen Hosp, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
来源：
CIRCULATION RESEARCH | 2020年 / 126卷 / 04期
关键词：
aging; epigenetics; exercise; heart failure; senescence; PRESERVED EJECTION FRACTION; MITOCHONDRIAL-DNA MUTATIONS; INDUCED CARDIAC-HYPERTROPHY; CLONAL HEMATOPOIESIS; LIFE-SPAN; CELLULAR SENESCENCE; OXIDATIVE STRESS; STEM-CELLS; CARDIOVASCULAR-DISEASE; TELOMERE DYSFUNCTION;
D O I：
10.1161/CIRCRESAHA.119.315889
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.
引用
收藏
页码：533 / 551
页数：19
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