Targeting Age-Related Pathways in Heart Failure

被引：185

作者：

Li Haobo ^{[1
]}

Hastings, Margaret H. ^{[1
]}

Rhee, James ^{[1
,2
]}

Trager, Lena E. ^{[1
]}

Roh, Jason D. ^{[1
]}

Rosenzweig, Anthony ^{[1
]}

机构：

[1] Harvard Med Sch, Corrigan Minehan Heart Ctr, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA

来源：

CIRCULATION RESEARCH | 2020年 / 126卷 / 04期

关键词：

aging; epigenetics; exercise; heart failure; senescence; PRESERVED EJECTION FRACTION; MITOCHONDRIAL-DNA MUTATIONS; INDUCED CARDIAC-HYPERTROPHY; CLONAL HEMATOPOIESIS; LIFE-SPAN; CELLULAR SENESCENCE; OXIDATIVE STRESS; STEM-CELLS; CARDIOVASCULAR-DISEASE; TELOMERE DYSFUNCTION;

D O I：

10.1161/CIRCRESAHA.119.315889

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.

引用

页码：533 / 551

页数：19

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