Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?

被引：28
作者：
Cai, Heng [1 ,2 ,3 ]
Liu, Wenjing [4 ]
Liu, Xiaobai [1 ,2 ,3 ]
Li, Zhiqing [1 ,2 ,3 ]
Feng, Tianda [1 ,2 ,3 ]
Xue, Yixue [5 ]
Liu, Yunhui [1 ,2 ,3 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Neurosurg, Shenyang 110004, Peoples R China
[2] Liaoning Clin Med Res Ctr Nervous Syst Dis, Shenyang 110004, Peoples R China
[3] Key Lab Neurooncol Liaoning Prov, Shenyang 110004, Peoples R China
[4] China Med Univ, Hosp 1, Dept Geriatr, Shenyang 110001, Peoples R China
[5] China Med Univ, Coll Basic Med, Dept Neurobiol, Shenyang 110122, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2020年 / 13卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
glioma; vasculogenic mimicry; glioma stem cells; hypoxia; drug delivery systems; noncoding RNAs; STEM-LIKE CELLS; TO-MESENCHYMAL TRANSITION; DRUG-DELIVERY; TUMOR-CELLS; VASCULAR MIMICRY; BLOOD-VESSELS; GLIOBLASTOMA; RESISTANCE; EXPRESSION; LIPOSOMES;
D O I：
10.2147/OTT.S247855
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Vasculogenic mimicry (VM) is the formation of a "vessel-like" structure without endothelial cells. VM exists in vascular-dependent solid tumors and is a special blood supply source involved in the highly invasive tumor progression. VM is observed in a variety of human malignant tumors and is closely related to tumor proliferation, invasion, and recurrence. Here, we review the mechanism, related signaling pathways, and molecular regulation of VM in glioma and discuss current research problems and the potential future applications of VM in glioma treatment. This review may provide a new viewpoint for glioma therapy.
引用
收藏
页码：4473 / 4483
页数：11
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