Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children

被引：25

作者：

Heidemann, Sabrina M. ^{[1
]}

Nair, Alison ^{[2
]}

Bulut, Yonca ^{[3
]}

Sapru, Anil ^{[2
,3
]}

机构：

[1] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA

[2] Univ Calif San Francisco, Dept Pediat, 550 16th St,Box 0110, San Francisco, CA 94143 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2017年 / 64卷 / 05期

关键词：

Acute respiratory distress syndrome; Pediatrics; Pathophysiology; Acute lung injury; PARDS; ACUTE LUNG INJURY; INHALED NITRIC-OXIDE; EXTRACORPOREAL MEMBRANE-OXYGENATION; END-EXPIRATORY PRESSURE; VON-WILLEBRAND-FACTOR; FREQUENCY OSCILLATORY VENTILATION; RANDOMIZED CONTROLLED-TRIAL; POTASSIUM CHANNEL TREK-1; RED-BLOOD-CELLS; MECHANICAL VENTILATION;

D O I：

10.1016/j.pcl.2017.06.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Acute respiratory distress syndrome (ARDS) is a syndrome of noncardiogenic pulmonary edema and hypoxia that accompanies up to 30% of deaths in pediatric intensive care units. Pediatric ARDS (PARDS) is diagnosed by the presence of hypoxia, defined by oxygenation index or Pao(2)/Fio(2) ratio cutoffs, and new chest infiltrate occurring within 7 days of a known insult. Hallmarks of ARDS include hypoxemia and decreased lung compliance, increased work of breathing, and impaired gas exchange. Mortality is often accompanied by multiple organ failure. Although many modalities to treat PARDS have been investigated, supportive therapies and lung-protective ventilator support remain the mainstay.

引用

页码：1017 / +

页数：22

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