iPSCs and DRGs: stepping stones to new pain therapies

被引：22

作者：

Alsaloum, Matthew ^{[1
,2
,3
,4
,5
]}

Waxman, Stephen G. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

[2] Yale Univ, Ctr Neurosci & Regenerat Res, West Haven, CT 06477 USA

[3] VA Connecticut Healthcare Syst, Ctr Rehabil Res, West Haven, CT 06516 USA

[4] Yale Sch Med, Yale Med Scientist Training Program, New Haven, CT USA

[5] Yale Sch Med, Interdept Neurosci Program, New Haven, CT USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; OF-FUNCTION MUTATIONS; RESISTANT SODIUM-CHANNELS; SPINAL SENSORY NEURONS; ROOT GANGLION NEURONS; NEUROVASCULAR COMPRESSION; TRIGEMINAL NEURALGIA; FIRING PROPERTIES; PACLITAXEL; NA(V)1.8;

D O I：

10.1016/j.molmed.2021.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is a pressing need for more effective nonaddictive treatment options for pain. Pain signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) neurons, whose excitability is driven by voltagepreferentially expressed in DRG neurons, play important roles in pain signaling in humans. Blockade of these channels may provide a novel approach to the treatment of pain, but clinical translation of preclinical results has been challenging, in part due to differences between rodent and human DRG neurons. Human DRG neurons and iPSC-derived sensory neurons (iPSC-SNs) provide new preclinical platforms that may facilitate the development of novel pain therapeutics.

引用

页码：110 / 122

页数：13

共 103 条

[1] A stop codon mutation in SCN9A causes lack of pain sensation [J].

Ahmad, Sultan ;

Dahllund, Leif ;

Eriksson, Anders B. ;

Hellgren, Dennis ;

Karlsson, Urban ;

Lund, Per-Eric ;

Meijer, Inge A. ;

Meury, Luc ;

Mills, Tracy ;

Moody, Adrian ;

Morinville, Anne ;

Morten, John ;

O'Donnell, Dajan ;

Raynoschek, Carina ;

Salter, Hugh ;

Rouleau, Guy A. ;

Krupp, Johannes J. .

HUMAN MOLECULAR GENETICS, 2007, 16 (17) :2114-2121

[2] Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7 [J].

Akin, Elizabeth J. ;

Alsaloum, Matthew ;

Higerd, Grant P. ;

Liu, Shujun ;

Zhao, Peng ;

Dib-Hajj, Fadia B. ;

Waxman, Stephen G. ;

Dib-Hajj, Sulayman D. .

BRAIN, 2021, 144 :1727-1737

[3] A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons [J].

Akopian, AN ;

Sivilotti, L ;

Wood, JN .

NATURE, 1996, 379 (6562) :257-262

[4] Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release [J].

Alexandrou, Aristos J. ;

Brown, Adam R. ;

Chapman, Mark L. ;

Estacion, Mark ;

Turner, Jamie ;

Mis, Malgorzata A. ;

Wilbrey, Anna ;

Payne, Elizabeth C. ;

Gutteridge, Alex ;

Cox, Peter J. ;

Doyle, Rachel ;

Printzenhoff, David ;

Lin, Zhixin ;

Marron, Brian E. ;

West, Christopher ;

Swain, Nigel A. ;

Storer, R. Ian ;

Stupple, Paul A. ;

Castle, Neil A. ;

Hounshell, James A. ;

Rivara, Mirko ;

Randall, Andrew ;

Dib-Hajj, Sulayman D. ;

Krafte, Douglas ;

Waxman, Stephen G. ;

Patel, Manoj K. ;

Butt, Richard P. ;

Stevens, Edward B. .

PLOS ONE, 2016, 11 (04)

[5] A novel gain-of-function sodium channel β2 subunit mutation in idiopathic small fiber neuropathy [J].

Alsaloum, Matthew ;

Labau, Julie I. R. ;

Sosniak, Daniel ;

Zhao, Peng ;

Almomani, Rowida ;

Gerrits, Monique ;

Hoeijmakers, Janneke G. J. ;

Lauria, Giuseppe ;

Faber, Catharina G. ;

Waxman, Stephen G. ;

Dib-Hajj, Sulayman .

JOURNAL OF NEUROPHYSIOLOGY, 2021, 126 (03) :827-839

[6] Status of peripheral sodium channel blockers for non-addictive pain treatment [J].

Alsaloum, Matthew ;

Higerd, Grant P. ;

Effraim, Philip R. ;

Waxman, Stephen G. .

NATURE REVIEWS NEUROLOGY, 2020, 16 (12) :689-705

[7] A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy [J].

Alsaloum, Matthew ;

Estacion, Mark ;

Almomani, Rowida ;

Gerrits, Monique M. ;

Boenhof, Gidon J. ;

Ziegler, Dan ;

Malik, Rayaz ;

Ferdousi, Maryam ;

Lauria, Giuseppe ;

Merkies, Ingemar S. J. ;

Faber, Catharina G. ;

Dib-Hajj, Sulayman ;

Waxman, Stephen G. ;

de Greef, B. ;

Hoeijmakers, J. G. J. ;

Sopacua, M. ;

Smeets, H. J. M. ;

Vanoevelen, J. M. ;

Eijkenboom, I ;

Lindsey, P. ;

Almomani, R. ;

Taiana, M. ;

Marchi, M. ;

Lombardi, R. ;

Cazzato, D. ;

Boneschi, F. M. ;

Zauli, A. ;

Clarelli, F. ;

Santoro, S. ;

Lopez, I ;

Quattrini, A. ;

Cestele, S. ;

Chever, O. ;

Tavakoli, M. ;

Malik, R. ;

Kapetis, D. ;

Xenakis, M. N. ;

Mantegazza, M. ;

Battiato, F. ;

Strom, A. .

MOLECULAR PAIN, 2019, 15

[8] Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma [J].

Bahmad, Hisham ;

Hadadeh, Ola ;

Chamaa, Farah ;

Cheaito, Katia ;

Darwish, Batoul ;

Makkawi, Ahmad-Kareem ;

Abou-Kheir, Wassim .

FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10

[9]

Baldini Angee, 2012, Prim Care Companion CNS Disord, V14, DOI 10.4088/PCC.11m01326

[10] THE ROLE OF VOLTAGE-GATED SODIUM CHANNELS IN PAIN SIGNALING [J].

Bennett, David L. ;

Clark, Alex J. ;

Huang, Jianying ;

Waxman, Stephen G. ;

Dib-Hajj, Sulayman D. .

PHYSIOLOGICAL REVIEWS, 2019, 99 (02) :1079-1151

← 1 2 3 4 5 6 7 8 9 10 →