PAF and haematopoiesis .4. Platelet-activating factor increases DNA synthesis in human bone marrow cells

被引：13
作者：
Denizot, Y
Dupuis, F
Trimoreau, F
Verger, C
Allegraud, A
Praloran, V
机构：
[1] Lab. d'Hematologie Experimentale, Faculté de Médecine, 87025 Limoges
来源：
JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING | 1996年 / 15卷 / 01期
关键词：
PAF; bone marrow cells; thymidine incorporation; haematopoiesis; human;
D O I：
10.1016/S0929-7855(96)00447-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Platelet-activating factor (PAF) is present in human bone marrow leading us to investigate its effect on human bone marrow cell proliferation. While PAF (0.1 mu M to 1 nM) stimulates the incorporation of [H-3]thymidine by freshly isolated adherent human bone marrow cells, PAF has no effect on non adherent cells. A non-metabolizable PAF agonist is more potent than PAF to stimulate thymidine incorporation in adherent cells. The precise role of PAF in human haematopoiesis in vivo remains to be clarified.
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页码：1 / 4
页数：4
相关论文
共 8 条
  • [1] PAF AND HEMATOPOIESIS .3. PRESENCE AND METABOLISM OF PLATELET-ACTIVATING-FACTOR IN HUMAN BONE-MARROW
    DENIZOT, Y
    TRIMOREAU, F
    DUPUIS, F
    VERGER, C
    PRALORAN, V
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1995, 1265 (01): : 55 - 60
  • [2] PAF AND HEMATOPOIESIS .5. PLATELET-ACTIVATING-FACTOR AND ACETYLHYDROLASE IN HUMAN FEMORAL BONE-MARROW
    DENIZOT, Y
    CHARISSOUX, JL
    NATHAN, N
    PRALORAN, V
    [J]. JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING, 1995, 12 (01): : 45 - 47
  • [3] DULIOUST A, 1988, J IMMUNOL, V140, P240
  • [4] KATO T, 1988, BIOCHEM BIOPH RES CO, V157, P363
  • [5] TISSUE ENGINEERING - RECONSTITUTION OF HUMAN HEMATOPOIESIS EX-VIVO
    KOLLER, MR
    PALSSON, BO
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 1993, 42 (08) : 909 - 930
  • [6] GUINEA-PIG BONE-MARROW CELLS TREATED WITH PLATELET-ACTIVATING-FACTOR GENERATE FACTOR(S) WHICH AFFECTS THEIR DNA-SYNTHESIS AND MICROBICIDAL ACTIVITY
    KUDO, I
    KATO, T
    HAYASHI, H
    YANOSHITA, R
    IKIZAWA, K
    UDA, H
    INOUE, K
    [J]. LIPIDS, 1991, 26 (12) : 1065 - 1070
  • [7] IMMUNOREGULATORY FUNCTIONS OF PAF-ACETHER .6. DUAL EFFECT ON HUMAN B-CELL PROLIFERATION
    LEPRINCE, C
    VIVIER, E
    TRETON, D
    GALANAUD, P
    BENVENISTE, J
    RICHARD, Y
    THOMAS, Y
    [J]. LIPIDS, 1991, 26 (12) : 1204 - 1208
  • [8] ROLAPLESZCZYNSKI M, 1988, J IMMUNOL, V140, P3547
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