Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma

被引：2

作者：

Yang, Naery ^{[1
]}

Mun, Yeung Chul ^{[2
]}

Seong, Chu-Myong ^{[2
]}

Huh, Hee Jin ^{[3
]}

Huh, Jungwon ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Med, Dept Lab Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea

[2] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[3] Dongguk Univ, Ilsan Med Ctr, Dept Lab Med, Goyang, South Korea

来源：

ANNALS OF LABORATORY MEDICINE | 2018年 / 38卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Hyperdiploidy; Multiple myeloma; Cytogenetics; High risk; PROGNOSTIC-SIGNIFICANCE; EGR1; CLASSIFICATION; TRISOMIES; NUMBER; MYC;

D O I：

10.3343/alm.2018.38.2.160

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM patients. To address this issue, we investigated the clinicopathological characteristics of HD with high-risk cytogenetics in MM. Ninety-seven patients with MM were included in the study. For metaphase cytogenetics (MC), unstimulated cells from bone marrow aspirates were cultured for either 24 or 48 hours. To detect HD by interphase fluorescence in situ hybridization (iFISH), we assessed trisomies of chromosomes 5, 7, 9, 11, 15, and 17. Of the 97 MM patients, 40 showed HD. The frequency of co-occurrence of HD and high-risk cytogenetics was 14% (14/97). When the clinicopathological characteristics were compared between the two groups of HD with high-risk cytogenetics vs. non-HD (NHD) with high-risk cytogenetics, the level of beta 2 microglobulin and stage distribution significantly differed (P=0.020, P=0.032, respectively). This study shows that some of the clinicopathological characteristics of MM patients with high-risk cytogenetics differ according to HD or NHD status.

引用

页码：160 / +

页数：11

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