Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer

被引：24

作者：

Cui, Yalei ^{[1
,2
]}

Yang, Xiaoyuan ^{[1
,2
]}

Zhang, Xiaobo ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Life Sci, 866 Yuhangtang Rd,Room 418, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Hangzhou 310058, Zhejiang, Peoples R China

来源：

MOLECULAR THERAPY-NUCLEIC ACIDS | 2017年 / 9卷

基金：

中国国家自然科学基金;

关键词：

LIPID-METABOLISM; VIRAL-INFECTION; TUMOR-GROWTH; MICRORNA; APOPTOSIS; DISEASE; PHAGOCYTOSIS; RECOGNITION; AUTOPHAGY; INVASION;

D O I：

10.1016/j.omtn.2017.10.016

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

During host stress response against virus infection, some animal microRNAs (miRNAs) can be upregulated to restore the virus-caused metabolic disorder of host cells via suppressing the expressions of miRNAs' target genes. These antiviral miRNAs may have antitumor capacity, because tumorigenesis results from metabolic disorder of cells. However, this subject has not been explored. In this study, the results showed that shrimp miR-34, which was upregulated during white spot syndrome virus (WSSV) infection, had antiviral activity in shrimp. The expression of shrimp miR-34 in breast cancer cells and in mice suppressed the growth and metastasis of breast cancer by targeting human CCND1, CDK6, CCNE2, E2F3, FOSL1, and MET genes in a cross-phylum manner. The results of this study indicated that miRNAs with antiviral activities can be promising sources for antitumor drug discovery.

引用

页码：387 / 398

页数：12

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