Silver-Promoted Synthesis of 5-[(Pentafluorosulfanyl)methyl]-2-oxazolines

被引：22

作者：

Gilbert, Audrey ^{[1
]}

Bertrand, Xavier ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, CGCC, PROTEO, Dept Chim, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

PENTAFLUOROSULFANYL; CHEMISTRY; SUBSTITUENTS; FLUORINE; ALCOHOLS; ANALOG; ACIDS;

D O I：

10.1021/acs.orglett.8b03170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 5-[(pentafluorosulfanyl)methyl]-2-oxazolines is reported. The use of a silver promoter allows the intramolecular cyclization of N-[2-chloro-3-(pentafluorosulfanyl)propyl] amide to occur without elimination of the chlorine atom, a reaction pathway typically observed for beta-chloro-SF5-alkyl compounds. The products, potentially valuable SF5-containing heterocycles, are obtained in up to 97% yield.

引用

页码：7257 / 7260

页数：4

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