Carnosine and Kidney Diseases: What We Currently Know?

被引：22

作者：

Kilis-Pstrusinska, Katarzyna ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Paediat Nephrol, Ul Borowska 213, PL-50556 Wroclaw, Poland

来源：

CURRENT MEDICINAL CHEMISTRY | 2020年 / 27卷 / 11期

关键词：

Carnosine; serum carnosinase; CNDP1; gene; chronic kidney disease; diabetic nephropathy; renoprotection; STAGE RENAL-DISEASE; HUMAN-SERUM CARNOSINASE; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; GENE CNDP1; INDUCED NEPHROTOXICITY; SYMPATHETIC-NERVE; LEUCINE REPEAT; METABOLISM; ASSOCIATION;

D O I：

10.2174/0929867326666190730130024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnosine (beta-alanyl-L-histidine) is an endogenously synthesised dipeptide which is present in different human tissues e.g. in the kidney. Camosine is degraded by enzyme serum carnosinase, encoding by CNDP1 gene. Camosine is engaged in different metabolic pathways in the kidney. It reduces the level of proinflamtnatory and profibrotic cytokines, inhibits advanced glycation end products' formation, moreover, it also decreases the mesangial cell proliferation. Carnosine may also serve as a scavenger of peroxyl and hydroxyl radicals and a natural angiotensin-converting enzyme inhibitor. This review summarizes the results of experimental and human studies concerning the role of carnosine in kidney diseases, particularly in chronic kidney disease, ischetnialreperfusion-induced acute renal failure, diabetic nephropathy and also drug -induced nephrotoxicity. The interplay between serum carnosine concentration and serum carnosinase activity and polymorphism in the CATDP1 gene is discussed. Carnosine has renoprotective properties. It has a promising potential for the treatment and prevention of different kidney diseases, particularly chronic kidney disease which is a global public health issue. Further studies of the role of carnosine in the kidney may offer innovative and effective strategies for the management of kidney diseases.

引用

页码：1764 / 1781

页数：18

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