Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery

被引：71
|
作者：
Gao, Wenxia [1 ,2 ]
Hu, Yalong [2 ]
Xu, Long [1 ]
Liu, Miaochang [2 ]
Wu, Huayue [2 ]
He, Bin [1 ]
机构：
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Low-molecular-weight gel; Glucose/pH sensitive; Gate controller; Mesoporous silica nanoparticles; Controlled release; RELEASE;
D O I：
10.1016/j.cclet.2018.05.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A low molecular weight gelator with dual pH and glucose sensitive moieties was synthesized. The gelator penetrated in the mesopores of silica nanoparticles (MSNs) and formed low molecular weight gel (LMWG) as gate to fabricate dual pH and glucose responsive nano drug delivery system. Antidiabetic drug was loaded in the gel caped MSNs, the drug release was responsive to the pH and glucose levels and the drug release could be controlled via the stimuli sensitivity of gel. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1795 / 1798
页数：4
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