Aldosterone Paradox: Differential Regulation of Ion Transport in Distal Nephron

被引：94

作者：

Pablo Arroyo, Juan ^{[1
,2
]}

Ronzaud, Caroline ^{[3
]}

Lagnaz, Dagmara ^{[3
]}

Staub, Olivier ^{[3
]}

Gamba, Gerardo ^{[1
,2
]}

机构：

[1] Univ Nacl Autonoma Mexico, Mol Physiol Unit, Inst Invest Biomed, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 04510, DF, Mexico

[2] Inst Nacl Cardiol Ignacio Chavez, Mexico City, DF, Mexico

[3] Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland

来源：

PHYSIOLOGY | 2011年 / 26卷 / 02期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

NA-CL COTRANSPORTER; PSEUDOHYPOALDOSTERONISM TYPE-II; SODIUM-CHLORIDE COTRANSPORTER; ALANINE-RICH KINASE; SURFACE EXPRESSION; BLOOD-PRESSURE; WNK KINASES; HYPOKALEMIC ALKALOSIS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MOLECULAR PATHOGENESIS;

D O I：

10.1152/physiol.00049.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K+ secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K+ balance.

引用

页码：115 / 123

页数：9

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