Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

被引：67

作者：

Furue, Kazuhisa ^{[1
]}

Ito, Takamichi ^{[1
]}

Furue, Masutaka ^{[1
,2
,3
]}

机构：

[1] Kyushu Univ, Dept Dermatol, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

[2] Kyushu Univ, Dept Dermatol, Div Skin Surface Sensing, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

[3] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

来源：

CYTOKINE | 2018年 / 111卷

关键词：

Psoriasis; Psoriatic arthritis; Biologics; efficacy; TNF-alpha/IL-23/IL-17; axis; SEVERE PLAQUE PSORIASIS; QUALITY-OF-LIFE; GENERALIZED PUSTULAR PSORIASIS; BODY-MASS INDEX; JAPANESE PATIENTS; DOUBLE-BLIND; CLINICAL-PRACTICE; SEVERITY INDEX; MONOCLONAL-ANTIBODY; INFLIXIMAB THERAPY;

D O I：

10.1016/j.cyto.2018.08.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-alpha/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-alpha/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-alpha remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-alpha/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.

引用

页码：182 / 188

页数：7

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