Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

被引：65
作者：
Furue, Kazuhisa [1 ]
Ito, Takamichi [1 ]
Furue, Masutaka [1 ,2 ,3 ]
机构：
[1] Kyushu Univ, Dept Dermatol, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan
[2] Kyushu Univ, Dept Dermatol, Div Skin Surface Sensing, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan
[3] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan
来源：
CYTOKINE | 2018年 / 111卷
关键词：
Psoriasis; Psoriatic arthritis; Biologics; efficacy; TNF-alpha/IL-23/IL-17; axis; SEVERE PLAQUE PSORIASIS; QUALITY-OF-LIFE; GENERALIZED PUSTULAR PSORIASIS; BODY-MASS INDEX; JAPANESE PATIENTS; DOUBLE-BLIND; CLINICAL-PRACTICE; SEVERITY INDEX; MONOCLONAL-ANTIBODY; INFLIXIMAB THERAPY;
D O I：
10.1016/j.cyto.2018.08.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-alpha/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-alpha/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-alpha remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-alpha/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.
引用
收藏
页码：182 / 188
页数：7
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