Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

被引：67

作者：

Furue, Kazuhisa ^{[1
]}

Ito, Takamichi ^{[1
]}

Furue, Masutaka ^{[1
,2
,3
]}

机构：

[1] Kyushu Univ, Dept Dermatol, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

[2] Kyushu Univ, Dept Dermatol, Div Skin Surface Sensing, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

[3] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

来源：

CYTOKINE | 2018年 / 111卷

关键词：

Psoriasis; Psoriatic arthritis; Biologics; efficacy; TNF-alpha/IL-23/IL-17; axis; SEVERE PLAQUE PSORIASIS; QUALITY-OF-LIFE; GENERALIZED PUSTULAR PSORIASIS; BODY-MASS INDEX; JAPANESE PATIENTS; DOUBLE-BLIND; CLINICAL-PRACTICE; SEVERITY INDEX; MONOCLONAL-ANTIBODY; INFLIXIMAB THERAPY;

D O I：

10.1016/j.cyto.2018.08.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-alpha/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-alpha/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-alpha remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-alpha/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.

引用

页码：182 / 188

页数：7

共 149 条

[1] Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial [J].

Abe, Masatoshi ;

Nishigori, Chikako ;

Torii, Hideshi ;

Ihn, Hironobu ;

Ito, Kei ;

Nagaoka, Makoto ;

Isogawa, Naoki ;

Kawaguchi, Isao ;

Tomochika, Yukiko ;

Kobayashi, Mihoko ;

Tallman, Anna M. ;

Papp, Kim A. .

JOURNAL OF DERMATOLOGY, 2017, 44 (11) :1228-1237

[2] Case of generalized pustular psoriasis exacerbated during pregnancy, successfully treated with infliximab [J].

Adachi, Akimasa ;

Komine, Mayumi ;

Hirano, Tomoko ;

Tsuda, Hidetoshi ;

Karakawa, Masaru ;

Murata, Satoru ;

Ohtsuki, Mamitaro .

JOURNAL OF DERMATOLOGY, 2016, 43 (12) :1439-1440

[3] Association of psoriasis with Hashimoto's thyroiditis, Sjogren's syndrome and dermatomyositis [J].

Akiyama, Michiko ;

Ueno, Takashi ;

Kanzaki, Akiko ;

Kuwana, Masataka ;

Nagao, Mototsugu ;

Saeki, Hidehisa .

JOURNAL OF DERMATOLOGY, 2016, 43 (06) :711-712

[4] Internalized stigma in psoriasis: A multicenter study [J].

Alpsoy, Erkan ;

Polat, Mualla ;

Fettahlioglu-Karaman, Bilge ;

Karadag, Ayse Serap ;

Kartal-Durmazlar, Pelin ;

Yalcin, Basak ;

Emre, Selma ;

Didar-Balci, Didem ;

Bilgic-Temel, Asli ;

Arca, Ercan ;

Koca, Rafet ;

Gunduz, Kamer ;

Borlu, Murat ;

Ergun, Tulin ;

Dogruk-Kacar, Seval ;

Cordan-Yazici, Ayca ;

Dursun, Pinar ;

Bilgic, Ozlem ;

Gunes-Bilgili, Serap ;

Sendur, Neslihan ;

Baysal, Ozge ;

Halil-Yavuz, Ibrahim ;

Yagcioglu, Gizem ;

Yilmaz, Ertan ;

Kavuzlu, Ufuk ;

Senol, Yesim .

JOURNAL OF DERMATOLOGY, 2017, 44 (08) :885-891

[5] Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: Response to therapy with biologics [J].

Asahina, Akihiko ;

Kubo, Naoko ;

Umezawa, Yoshinori ;

Honda, Hiromi ;

Yanaba, Koichi ;

Nakagawa, Hidemi .

JOURNAL OF DERMATOLOGY, 2017, 44 (10) :1112-1121

[6] Safety and efficacy of adalimumab treatment in Japanese patients with psoriasis: Results of SALSA study [J].

Asahina, Akihiko ;

Torii, Hideshi ;

Ohtsuki, Mamitaro ;

Tokimoto, Toshimitsu ;

Hase, Hidenori ;

Tsuchiya, Tsuyoshi ;

Shinmura, Yasuhiko ;

Servin, Ofelia Reyes ;

Nakagawa, Hidemi .

JOURNAL OF DERMATOLOGY, 2016, 43 (11) :1257-1266

[7] Oral tofacitinib efficacy, safety and tolerability in Japanese patients with moderate to severe plaque psoriasis and psoriatic arthritis: A randomized, double-blind, phase 3 study [J].

Asahina, Akihiko ;

Etoh, Takafumi ;

Igarashi, Atsuyuki ;

Imafuku, Shinichi ;

Saeki, Hidehisa ;

Shibasaki, Yoshiyuki ;

Tomochika, Yukiko ;

Toyoizumi, Shigeyuki ;

Nagaoka, Makoto ;

Ohtsuki, Mamitaro .

JOURNAL OF DERMATOLOGY, 2016, 43 (08) :869-880

[8] Serum C-reactive protein levels in Japanese patients with psoriasis and psoriatic arthritis: Long-term differential effects of biologics [J].

Asahina, Akihiko ;

Umezawa, Yoshinori ;

Yanaba, Koichi ;

Nakagawa, Hidemi .

JOURNAL OF DERMATOLOGY, 2016, 43 (07) :779-784

[9] TUR-PSO: A cross-sectional, study investigating quality of life and treatment status of psoriasis patients in Turkey [J].

Atakan, Nilgun ;

Yazici, Ayca Cordan ;

Ozarmagan, Guzin ;

Inaloz, Huseyin Serhat ;

Gurer, Mehmet Ali ;

Sabuncu, Ilham ;

Kiremitci, Ummuhan ;

Alper, Sibel ;

Aytekin, Sema ;

Arican, Ozer ;

Polat, Mualla ;

Dogan, Sibel ;

Aldinc, Emre .

JOURNAL OF DERMATOLOGY, 2016, 43 (03) :298-304

[10] Algorithm to select optimal systemic anti-psoriatic drugs in relation with patients' Psoriasis Area and Severity Index score for plaque psoriasis [J].

Bae, Soo Hyeon ;

Yun, Sook Jung ;

Lee, Jee-Bum ;

Kim, Seong-Jin ;

Won, Young Ho ;

Lee, Seung-Chul .

JOURNAL OF DERMATOLOGY, 2016, 43 (06) :643-649

← 1 2 3 4 5 6 7 8 9 10 →