Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children

被引：21
作者：
Riikonen, Raili [1 ,2 ]
机构：
[1] Univ Eastern Finland, Childrens Hosp, Child Neurol, POB 1627, FI-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, POB 1627, FI-70211 Kuopio, Finland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期
关键词：
insulin-like growth factor; pathogenesis; neonates; neurodevelopmental disorders; neurodegeneration; neuroprotection; children; NEURONAL CEROID-LIPOFUSCINOSIS; AUTISTIC-LIKE BEHAVIOR; FACTOR-I; CEREBROSPINAL-FLUID; RETT-SYNDROME; PROGRESSIVE ENCEPHALOPATHY; NEUROTROPHIC FACTOR; MOUSE MODEL; IGF-I; SEROTONIN TRANSPORTER;
D O I：
10.3390/ijms18102056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy-hypsarrhythmia-optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD).
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页数：18
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