Isolation and characterization of H5Nx highly pathogenic avian influenza viruses of Glade 2.3.4.4 in Russia

被引：25
作者：
Marchenko, V. [1 ]
Goncharova, N. [1 ]
Susloparov, I. [1 ]
Kolosova, N. [1 ]
Gudymo, A. [1 ]
Svyatchenko, S. [1 ]
Danilenko, A. [1 ]
Durymanov, A. [1 ]
Gavrilova, E. [1 ]
Maksyutov, R. [1 ]
Ryzhikov, A. [1 ]
机构：
[1] State Res Ctr Virol & Biotechnol Vector, Koltsov, Novosibirsk Reg, Russia
来源：
VIROLOGY | 2018年 / 525卷
关键词：
HPAI; Avian influenza; H5N8; H5N2; H5N5; Surveillance; Russia; A VIRUS; VIRULENCE; RESIDUES; BERINGIA; POULTRY; A(H5N8); BIRDS;
D O I：
10.1016/j.virol.2018.09.024
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In 2016-2017, several subtypes of the highly pathogenic avian influenza (HPAI) virus were isolated on the territory of Russia. In the autumn of 2016, during the avian influenza virus surveillance in the territory of the Kamchatka region of Russia the HPAI A(H5N5) influenza virus was isolated. Then, during 2016-2017, multiple outbreaks among wild birds and poultry caused by HPAI A(H5N8) avian influenza virus were recorded in European part of Russia. At the end of 2017, an outbreak among poultry caused by HPAI A(H5N2) influenza virus was recorded in the European part of Russia. Phylogenetic analysis of HA of the A(H5N5), A(H5N8), A(H5N2) showed the strains belong to the Glade 2.3.4.4 b. All isolated strains were antigenically closely related to candidate vaccine viruses of Glade 2.3.4.4 and showed high virulence in mice. Genetic analysis revealed presence of genetic markers potentially related to high virulence in mice in all studied viruses.
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收藏
页码：216 / 223
页数：8
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